Product image of Nimotop (Nimodipine) supplied by GNH India

Nimotop

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop (Nimodipine)

Nimodipine, the active ingredient in Nimotop, is a calcium channel blocker (dihydropyridine) presented as a 30 mg oral tablet for oral use. It is used for prevention of cerebral vasospasm following subarachnoid hemorrhage in patients at risk.

GNH India supplies Nimotop as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nimodipine is employed in the management of cerebral vasospasm, a vascular complication following subarachnoid hemorrhage.

  • Subarachnoid hemorrhage: prevention of cerebral vasospasm
  • Delayed ischemic neurological deficit: reduction of incidence after SAH
  • Cerebral blood flow impairment: improvement of perfusion following SAH

How It Works

  • Nimodipine selectively antagonizes L‑type calcium channels, with a higher affinity for vascular smooth‑muscle cells in cerebral arteries. By blocking calcium influx, it induces vasodilation of intracranial vessels, improves cerebral blood flow, and reduces calcium‑mediated neuronal injury that can follow subarachnoid hemorrhage.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity
  • Dizziness or light‑headedness: especially on standing
  • Flushing or warmth sensation: transient
  • Nausea or abdominal discomfort: occasional

Serious or Rare Side Effects

  • Severe hypotension: may require medical intervention
  • Bradycardia or heart block: monitor cardiac rhythm
  • Hepatic dysfunction: elevated liver enzymes
  • Allergic reactions: rash, pruritus, or angioedema
  • Rare skin disorders: Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before initiating Nimodipine therapy, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for symptomatic hypotension
  • Assess hepatic function: adjust use if liver impairment is present
  • Avoid strong CYP3A4 inhibitors: may increase drug exposure
  • Use caution in elderly patients: increased sensitivity to hemodynamic changes
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nimodipine can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause toxicity
  • Concomitant antihypertensives: additive hypotensive effect

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy
  • Grapefruit juice: can increase plasma concentrations
  • Other calcium‑channel blockers: may enhance cardiovascular effects

Frequently Asked Questions

Nimotop contains nimodipine, which is prescribed to prevent cerebral vasospasm after a subarachnoid hemorrhage. By maintaining adequate blood flow in the brain’s vessels, it helps reduce the risk of delayed ischemic neurological deficits in patients who have experienced this type of bleeding.

Nimodipine selectively blocks L‑type calcium channels in the smooth muscle of cerebral arteries. This action relaxes the vessels, leading to vasodilation, improved cerebral perfusion, and a decrease in calcium‑induced neuronal injury that can follow a subarachnoid hemorrhage.

The dosage of Nimotop is determined by the prescribing clinician based on the patient’s condition, weight, and renal or hepatic function. The prescriber will specify the exact amount and frequency on the prescription label.

The safety of nimodipine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Nimotop, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is distinguished by its preferential activity in cerebral vessels, whereas many other calcium‑channel blockers target systemic vasculature. This selectivity makes nimodipine especially suitable for preventing vasospasm after subarachnoid hemorrhage, while other agents are typically used for hypertension or angina.

Nimotop tablets should be stored at ambient temperature below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency throughout its shelf life.

Nimotop is taken orally as a tablet, usually with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless specifically instructed by a healthcare professional.

The most serious risks include severe hypotension, bradycardia, and rare but potentially life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of low blood pressure, abnormal heart rhythms, or any severe skin changes, and seek immediate medical attention if they occur.

Nimotop is contraindicated in patients with known hypersensitivity to nimodipine or any other dihydropyridine calcium‑channel blockers. Caution is also advised for individuals with severe hepatic impairment, uncontrolled hypotension, or those taking potent CYP3A4 inhibitors without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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