Product image of Nimotop (Nimodipine) supplied by GNH India

Nimotop

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop (Nimodipine)

Nimodipine, the active ingredient in Nimotop, is a calcium channel blocker presented as a 30 mg tablet for oral use. It is used to prevent cerebral vasospasm after subarachnoid hemorrhage and to treat other cerebrovascular disorders in adult patients.

GNH India supplies Nimotop as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Plc

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Indications & Clinical Uses

Nimodipine is indicated for conditions involving the cerebral vasculature where vasospasm or reduced blood flow is a concern.

  • Prevention of cerebral vasospasm after subarachnoid hemorrhage: reduces the risk of delayed ischemic neurological deficits.
  • Treatment of cerebral vasospasm: promotes cerebral blood flow to mitigate ischemia.
  • Management of other cerebrovascular disorders: improves cerebral perfusion in selected adult patients.

How It Works

  • Nimodipine selectively inhibits L‑type calcium channels in vascular smooth muscle of cerebral arteries, decreasing calcium influx. This action leads to relaxation of the arterial wall, resulting in cerebral vasodilation and enhanced blood flow to brain tissue, which helps prevent ischemic complications after vascular injury.

Side Effects

Adverse reactions may occur with nimodipine therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Dizziness: often related to blood pressure changes.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Hypotension: significant drop in blood pressure requiring medical attention.
  • Bradycardia: unusually slow heart rate.
  • Allergic reactions: rash, angioedema, or anaphylaxis in rare cases.

Precautions & Warnings

When prescribing nimodipine, several safety considerations are important.

  • Pregnancy: Category B; use only if the potential benefit justifies the potential risk.
  • Breastfeeding: Caution; monitor the infant for any adverse effects.
  • Renal impairment: Adjust dosing if renal function is markedly reduced.
  • Hepatic impairment: Use with caution; liver disease may affect drug metabolism.
  • Concomitant antihypertensives: Monitor blood pressure closely to avoid excessive hypotension.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nimodipine may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations of nimodipine.
  • Other potent vasodilators (e.g., nitroglycerin): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • NSAIDs: may blunt the antihypertensive effect of nimodipine.
  • Beta‑blockers: additive effects on heart rate and blood pressure.

Frequently Asked Questions

Nimotop contains nimodipine and is indicated to prevent cerebral vasospasm after subarachnoid hemorrhage and to treat certain cerebrovascular disorders in adults, helping to maintain adequate cerebral blood flow.

Nimodipine blocks L‑type calcium channels in the smooth muscle of cerebral arteries, reducing calcium entry, which relaxes the vessels and produces selective vasodilation of brain vessels, thereby improving perfusion.

The prescribed dose is determined by the treating physician based on the clinical situation. Typical regimens involve oral administration of 30 mg tablets, but the exact frequency and duration are individualized for each patient.

Nimodipine is classified as pregnancy category B, indicating no evidence of risk in animal studies, but it should be used only if the potential benefit outweighs any potential risk. Caution is advised during breastfeeding, and the infant should be monitored.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Nimodipine is more lipophilic and has a higher affinity for cerebral vessels than many systemic calcium channel blockers, providing targeted brain vasodilation. Other agents such as nicardipine act more broadly on systemic vasculature and are not as selective for cerebral arteries.

Store tablets at ambient temperature below 25 °C, in the original blister pack, protected from moisture and direct sunlight. Do not refrigerate or freeze the product.

Nimotop is taken orally, usually with a glass of water. The tablet should be swallowed whole unless a healthcare professional advises otherwise; it is not intended to be crushed or chewed.

The most serious adverse reactions include severe hypotension, bradycardia, and hypersensitivity reactions such as rash or angioedema. Patients experiencing these symptoms should seek immediate medical attention.

Nimotop is contraindicated in individuals with known hypersensitivity to nimodipine or other dihydropyridine calcium channel blockers, and should be used with caution in patients with severe hypotension, uncontrolled heart failure, or significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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