Product image of Nimotop (Nimodipine) supplied by GNH India

Nimotop

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop (Nimodipine)

Nimodipine, the active ingredient in Nimotop, is a calcium channel blocker presented as an intravenous formulation for intravenous use. It is used to prevent cerebral vasospasm following subarachnoid hemorrhage in patients at risk of delayed ischemic neurological deficits.

GNH India supplies Nimotop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nimotop acts on the cerebrovascular system to reduce the risk of vasospasm after hemorrhagic events.

  • Subarachnoid hemorrhage: helps prevent delayed cerebral vasospasm.
  • Cerebral vasospasm: reduces vessel narrowing after hemorrhage.
  • Neurological outcome after SAH: improves recovery by maintaining cerebral blood flow.

How It Works

  • Nimodipine selectively blocks L‑type calcium channels in vascular smooth muscle, decreasing calcium influx. This leads to relaxation of cerebral arteries, improved cerebral blood flow, and neuroprotective effects that mitigate the consequences of vasospasm after subarachnoid hemorrhage.

Side Effects

Adverse reactions may occur with nimodipine therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Hypotension: transient blood pressure drop.
  • Nausea: occasional gastrointestinal upset.
  • Flushing: warm sensation with reddening of skin.
  • Dizziness: sensation of light‑headedness.
  • Bradycardia: slower than normal heart rate.

Serious or Rare Side Effects

  • Severe hypotension: may require medical intervention.
  • Hepatic enzyme elevation: monitor liver function tests.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Cardiac arrhythmias: rare but potentially life‑threatening.

Precautions & Warnings

Before initiating Nimotop, consider the following safety measures.

  • Monitor blood pressure: watch for excessive hypotension.
  • Review concomitant antihypertensives: avoid additive blood pressure effects.
  • Assess hepatic function: dose adjustment may be needed in impairment.
  • Avoid strong CYP3A4 inhibitors: they can raise nimodipine levels.
  • Observe for allergic signs: discontinue if severe reaction occurs.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Nimodipine may interact with several drug classes.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase plasma concentrations.
  • Concomitant antihypertensives: cause additive hypotensive effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): reduce therapeutic levels.
  • Other calcium channel blockers: may enhance hypotension.
  • NSAIDs: potential impact on renal function when combined.
  • Beta‑blockers: monitor for bradycardia.

Frequently Asked Questions

Nimotop contains nimodipine and is indicated to prevent cerebral vasospasm after subarachnoid hemorrhage, helping to reduce the risk of delayed ischemic neurological deficits in affected patients.

Nimodipine blocks L‑type calcium channels in the smooth muscle of cerebral arteries, decreasing calcium entry, which relaxes the vessels, improves cerebral blood flow, and provides neuroprotection against vasospasm‑related injury.

The prescribed dose of Nimotop is determined by the treating physician based on the patient’s clinical condition, weight, and response. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for nimodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the Nimotop product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is specifically formulated for cerebral vasodilation and neuroprotection, whereas many other calcium channel blockers target systemic blood pressure control. Its lipophilicity allows better penetration of the blood‑brain barrier, making it the preferred choice for preventing vasospasm after subarachnoid hemorrhage.

Store Nimotop at room temperature, below 25 °C, in the original packaging. Protect it from moisture, direct sunlight, and extreme temperature fluctuations to maintain product stability.

Nimotop is given intravenously by a healthcare professional. The infusion rate and duration are set by the prescriber, typically administered over a defined period under continuous monitoring of vital signs.

Serious risks include severe hypotension, hepatic enzyme elevation, and rare allergic reactions such as anaphylaxis. Prompt recognition and medical management are essential if these events occur.

Patients with known hypersensitivity to nimodipine or any component of the formulation, those with uncontrolled severe hypotension, and individuals taking contraindicated strong CYP3A4 inhibitors should avoid using Nimotop.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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