Product image of Nimotop (Nimodipine) supplied by GNH India

Nimotop

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop (Nimodipine)

Nimodipine, the active ingredient in Nimotop, is a calcium channel blocker presented as an intravenous solution for intravenous use. It is employed to prevent cerebral vasospasm after aneurysmal subarachnoid hemorrhage in adult patients. By selectively antagonising L‑type calcium channels in cerebral arteries, it helps maintain adequate cerebral blood flow during the critical post‑hemorrhage period.

GNH India supplies Nimotop as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

  • Nimodipine is used in the management of cerebrovascular complications associated with subarachnoid hemorrhage.
  • Aneurysmal subarachnoid hemorrhage: reduces the incidence of delayed cerebral ischemia.
  • Cerebral vasospasm after SAH: promotes arterial dilation to improve cerebral perfusion.
  • Neurological outcome after SAH: contributes to better functional recovery in affected patients.

How It Works

  • Nimodipine selectively blocks L‑type voltage‑gated calcium channels located on smooth muscle cells of cerebral arteries. This inhibition reduces calcium influx, causing vasodilation of intracranial vessels, which improves cerebral blood flow and lowers the risk of vasospasm following aneurysmal subarachnoid hemorrhage.

Side Effects

Nimodipine may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache
  • Hypotension
  • Nausea
  • Flushing
  • Dizziness
  • Tachycardia

Serious or Rare Side Effects

  • Severe hypotension leading to syncope
  • Myocardial infarction or ischemia
  • Hepatic dysfunction or elevated transaminases
  • Anaphylactic or severe allergic reactions
  • Seizures (rare)

Precautions & Warnings

  • When using Nimotop, clinicians should observe several precautionary measures to ensure patient safety.
  • Blood pressure monitoring: check systolic and diastolic values regularly during infusion.
  • Hepatic function: adjust use in patients with severe liver impairment.
  • Cardiac disease: avoid rapid infusion in patients with unstable angina or recent myocardial infarction.
  • Concomitant vasodilators: use cautiously with other agents that lower blood pressure.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Nimodipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may markedly increase plasma concentrations.
  • Concurrent potent vasodilators (e.g., nitroglycerin, hydralazine): risk of severe hypotension.
  • Other calcium channel blockers (e.g., verapamil, diltiazem): additive cardiovascular effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance bradycardia or hypotension.
  • Diuretics: can potentiate blood pressure lowering.
  • Macrolide antibiotics (e.g., erythromycin): may modestly increase nimodipine levels.

Frequently Asked Questions

Nimotop contains nimodipine and is indicated for the prevention of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. It helps maintain cerebral blood flow during the period when patients are at risk of delayed ischemic neurological deficits.

Nimodipine selectively blocks L‑type calcium channels in the smooth muscle of cerebral arteries. This reduces calcium entry, causing vasodilation of intracranial vessels, which improves perfusion and lowers the chance of vasospasm after a subarachnoid bleed.

The dosing regimen for Nimotop is determined by the treating physician based on the patient’s clinical condition, weight, and response. No fixed public dose is provided; prescribers set the appropriate infusion rate and duration.

Safety data for nimodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Nimotop, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Nimodipine is more selective for cerebral vessels than many other calcium channel blockers, resulting in fewer peripheral hypotensive effects. This selectivity makes it the preferred agent for preventing vasospasm after subarachnoid hemorrhage, whereas other blockers are generally used for systemic hypertension.

Nimotop should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability.

Nimotop is given as an intravenous infusion under medical supervision. The infusion rate and duration are set by the prescribing clinician, and patients are monitored continuously for blood pressure and cardiac status during administration.

The most serious adverse events include severe hypotension, myocardial infarction or ischemia, hepatic dysfunction, and rare but potentially life‑threatening allergic reactions such as anaphylaxis. Prompt recognition and management are essential.

Nimotop is contraindicated in patients with known hypersensitivity to nimodipine or any component of the formulation, those with uncontrolled severe hypotension, recent myocardial infarction, or unstable cardiac disease. Caution is also advised in severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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