Product image of Nimotop S (Nimodipine) supplied by GNH India

Nimotop S

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop S (Nimodipine)

Nimodipine, the active ingredient in Nimotop S, is a calcium channel blocker presented as an oral tablet for oral use. It prevents and treats cerebral vasospasm following subarachnoid hemorrhage.
GNH India supplies Nimotop S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nimodipine is used to address vascular complications within the central nervous system, particularly after subarachnoid hemorrhage.

  • Cerebral vasospasm after subarachnoid hemorrhage: reduces vasoconstriction and improves cerebral blood flow.
  • Neuroprotection after subarachnoid hemorrhage: helps limit secondary neuronal injury and ischemic deficits.

How It Works

  • Nimodipine selectively blocks L‑type calcium channels in vascular smooth‑muscle and neuronal cells, decreasing calcium influx. This leads to dilation of cerebral arteries, improved cerebral perfusion, and reduced calcium‑mediated neuronal injury, providing both vasodilatory and neuroprotective effects.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Hypotension: transient drops in blood pressure.
  • Nausea: occasional gastrointestinal upset.
  • Flushing: warmth and redness of skin.
  • Dizziness: especially when standing quickly.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: may require medical intervention.
  • Myocardial infarction: rare cardiac events.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Blood dyscrasias: thrombocytopenia or leukopenia.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Renal impairment: assess renal function and monitor for accumulation.
  • Hepatic impairment: use with caution and observe liver enzymes.
  • Hypotension: monitor blood pressure regularly, especially after dose initiation.
  • Concomitant vasodilators: increased risk of additive blood‑pressure lowering effects.
  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nimodipine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower effectiveness.
  • Other calcium‑channel blockers: additive vasodilatory effect leading to profound hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: enhanced hypotensive response.
  • Nitrates: increased risk of low blood pressure.
  • Diuretics: may potentiate orthostatic hypotension.

Frequently Asked Questions

Nimotop S contains nimodipine, which is prescribed to prevent and treat cerebral vasospasm that can occur after a subarachnoid hemorrhage. By improving blood flow in the brain’s arteries, it helps reduce the risk of delayed neurological deficits in affected patients.

Nimodipine selectively blocks L‑type calcium channels in vascular smooth‑muscle and neuronal cells. This inhibition reduces calcium entry, causing dilation of cerebral arteries, enhancing cerebral perfusion, and providing neuroprotective effects that limit calcium‑mediated neuronal injury.

The appropriate dose of Nimotop S is determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and other individual factors. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for nimodipine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Nimotop S product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nimodipine is a dihydropyridine calcium‑channel blocker with a high affinity for cerebral vessels, offering both vasodilation and neuroprotection. Compared with non‑selective vasodilators, it provides targeted cerebral effects while minimizing systemic hypotension, making it the preferred choice for subarachnoid hemorrhage‑related vasospasm.

Nimotop S should be stored at ambient temperature below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Nimotop S is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional. Administration timing and frequency are set by the prescribing clinician.

The most serious risks include severe hypotension, myocardial infarction, hepatic dysfunction, and rare allergic reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these events, and any sudden changes in blood pressure or liver function should prompt immediate medical evaluation.

Nimotop S is contraindicated in patients with known hypersensitivity to nimodipine or any component of the formulation. It should also be avoided in individuals with severe uncontrolled hypotension or in whom the risks of vasodilation outweigh potential benefits, as determined by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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