Product image of Nimotop S (Nimodipine) supplied by GNH India

Nimotop S

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop S (Nimodipine)

Nimodipine, the active ingredient in Nimotop S, is a calcium channel blocker presented as an oral tablet for oral use. It is used to prevent cerebral vasospasm after subarachnoid hemorrhage and to treat neurovascular disorders.

GNH India supplies Nimotop S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nimodipine is indicated for conditions involving cerebral vasospasm and other neurovascular disorders.

  • Subarachnoid hemorrhage (post‑aneurysmal): Prevention of cerebral vasospasm following hemorrhage.
  • Cerebral vasospasm: Dilates cerebral vessels to improve blood flow.
  • Neurovascular disorders: Provides neuroprotection in selected cerebrovascular conditions.

How It Works

  • Nimodipine acts as an L‑type calcium channel antagonist, preferentially blocking calcium influx in cerebral arterial smooth muscle. This inhibition leads to relaxation of cerebral vessels, increased cerebral blood flow, and reduced calcium‑mediated neuronal injury, thereby offering neuroprotective effects during ischemic events.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness.
  • Nausea or gastrointestinal discomfort.
  • Flushing or warmth sensation.

Serious or Rare Side Effects

  • Hypotension: significant drop in blood pressure.
  • Bradycardia: unusually slow heart rate.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Nimodipine, clinicians should consider several precautionary measures to ensure safe use.

  • Cardiovascular status: monitor blood pressure and heart rate due to possible hypotension.
  • Hepatic impairment: use with caution; dose adjustment may be required.
  • Concomitant vasodilators: avoid additive blood pressure lowering effects.
  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Elderly patients: start at lower dose and monitor for dizziness.
  • Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture.

Avoid Interactions

Nimodipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase Nimodipine plasma levels.
  • Concurrent use with other potent vasodilators (e.g., nitroglycerin): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce effectiveness.
  • Beta‑blockers: additive effect on heart rate and blood pressure.
  • Diuretics: may enhance hypotensive response.

Frequently Asked Questions

Nimotop S contains nimodipine, which is prescribed to prevent cerebral vasospasm after subarachnoid hemorrhage and to provide neuroprotection in various neurovascular disorders. It works by dilating cerebral vessels, helping maintain adequate blood flow to the brain during critical periods.

Nimodipine selectively blocks L‑type calcium channels in the smooth muscle of cerebral arteries. By reducing calcium entry, it relaxes these vessels, increases cerebral blood flow, and limits calcium‑induced neuronal injury, thereby offering protective effects during ischemic events.

The dosage of Nimotop S is determined by the prescribing clinician based on the patient’s condition, severity, and individual response. Healthcare professionals adjust the regimen according to clinical guidelines and patient-specific factors.

Safety data for nimodipine in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so it should only be used if the potential benefit justifies the potential risk to the fetus or infant. Consultation with a specialist is essential.

To request Nimotop S, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is distinguished by its high affinity for cerebral vessels, offering targeted vasodilation and neuroprotection not typically seen with generic calcium channel blockers such as amlodipine. This makes it the preferred choice for managing cerebral vasospasm after subarachnoid hemorrhage.

Nimotop S should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Nimotop S is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically directed by a healthcare professional. Administration timing follows the prescriber’s instructions.

Serious risks include significant hypotension, bradycardia, and rare allergic reactions such as rash, swelling, or anaphylaxis. Patients should be monitored for sudden drops in blood pressure or heart rate, and any signs of an allergic response require immediate medical attention.

Nimotop S is contraindicated in patients with known hypersensitivity to nimodipine or other calcium channel blockers. Caution is also advised for individuals with severe hepatic impairment, uncontrolled hypotension, or those taking interacting medications that could exacerbate blood pressure reductions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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