Product image of Nimotop S (Nimodipine) supplied by GNH India

Nimotop S

Active Ingredient:
Nimodipine
Origin:
EU

Nimotop S (Nimodipine)

Nimodipine, the active ingredient in Nimotop S, is a calcium channel blocker presented as an oral dosage form for oral use. It is employed to prevent cerebral vasospasm following subarachnoid hemorrhage, improving cerebral blood flow in affected patients and may contribute to neurological recovery.

GNH India supplies Nimotop S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. The company adheres to stringent manufacturing standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Laboratoire Xo

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Indications & Clinical Uses

Nimodipine is a calcium channel blocker used primarily in the management of cerebrovascular complications.

  • Prevention of cerebral vasospasm following subarachnoid hemorrhage: reduces the risk of delayed ischemic neurological deficits by promoting cerebral vasodilation.
  • Aneurysmal subarachnoid hemorrhage after surgical repair: helps prevent delayed vasospasm and supports recovery.
  • Acute neurological injury with risk of cerebral ischemia: used as adjunctive therapy to improve cerebral blood flow.

How It Works

  • Nimodipine selectively blocks L-type calcium channels on vascular smooth‑muscle cells, decreasing calcium influx. This inhibition leads to relaxation of cerebral arteries, producing vasodilation that enhances cerebral blood flow and provides neuroprotective effects in the setting of subarachnoid hemorrhage.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Hypotension: transient drop in blood pressure.
  • Nausea: occasional gastrointestinal upset.
  • Flushing: warm sensation with reddening of skin.
  • Dizziness: sensation of light‑headedness.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure reduction requiring medical attention.
  • Bradycardia: unusually slow heart rate.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reaction: rash, itching, or swelling.
  • Neutropenia: low white‑blood‑cell count.
  • Myocardial infarction: rare cardiac event.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: watch for symptomatic hypotension.
  • Assess liver function: adjust use in hepatic impairment.
  • Avoid strong CYP3A4 inhibitors: may increase nimodipine plasma levels.
  • Use caution in elderly patients: increased sensitivity to vasodilatory effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nimodipine can interact with other medicines that affect cardiovascular tone or metabolism.

Major Interactions (Avoid)

  • Concurrent use with other potent vasodilators: risk of severe hypotension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma concentrations.
  • Combined use with beta‑blockers: additive cardiovascular depression.

Moderate Interactions (Monitor Closely)

  • Co‑administration with other calcium channel blockers (e.g., amlodipine): monitor blood pressure.
  • Diuretics: may enhance hypotensive effect.
  • Other antihypertensive agents: dose adjustments may be required.

Frequently Asked Questions

Nimotop S contains nimodipine, a calcium channel blocker that is specifically indicated to prevent cerebral vasospasm after subarachnoid hemorrhage. By dilating cerebral arteries, it helps maintain adequate blood flow to the brain and reduces the risk of delayed ischemic neurological deficits.

Nimodipine selectively blocks L‑type calcium channels on the smooth muscle of cerebral vessels. This reduces calcium entry into the cells, causing relaxation of the arterial wall, vasodilation, and improved cerebral perfusion, which provides neuroprotective benefits in the setting of hemorrhage.

The dosage of Nimotop S is determined by the prescribing clinician based on the patient’s condition, weight, and renal or hepatic function. The prescriber will set the appropriate strength, frequency, and duration according to current clinical guidelines.

Safety data for nimodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Nimotop S, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is distinguished by its high lipophilicity and preferential action on cerebral vessels, whereas many other calcium channel blockers affect systemic vasculature more broadly. This selectivity makes it particularly useful for preventing vasospasm after subarachnoid hemorrhage, a benefit not shared by all vasodilators.

Nimotop S should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Nimotop S is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Administration timing and frequency are set by the prescribing physician.

The most serious adverse events include severe hypotension, bradycardia, hepatic dysfunction, and rare allergic reactions. Patients should be monitored for signs of low blood pressure, abnormal heart rate, or liver enzyme changes, and any concerning symptoms should be reported promptly.

Nimotop S is contraindicated in patients with known hypersensitivity to nimodipine or any component of the formulation. Caution is advised for individuals with severe hypotension, advanced heart block, or significant hepatic impairment, and it should be avoided in these situations unless a physician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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