Product image of Nimra (Tranexamic Acid) supplied by GNH India

Nimra

Active Ingredient:
Tranexamic Acid
Origin:
EU

Nimra (Tranexamic Acid)

Tranexamic Acid, the active ingredient in Nimra, is an antifibrinolytic presented as an oral formulation for prescription use. It reduces fibrinolysis by inhibiting plasmin formation, thereby stabilizing blood clots. Clinically, it is employed to control excessive menstrual bleeding, minimize intra‑operative blood loss, and manage trauma‑related hemorrhage under physician guidance.

GNH India supplies Nimra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Cemag Care

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Indications & Clinical Uses

Tranexamic Acid is used to reduce bleeding in several clinical situations involving the hemostatic pathway.

  • Menorrhagia: helps reduce the volume and duration of menstrual bleeding in women with heavy periods.
  • Surgical bleeding: decreases intra‑operative blood loss and the need for transfusion during various surgical procedures.
  • Trauma-related hemorrhage: assists in controlling acute bleeding following traumatic injuries.

How It Works

  • Tranexamic Acid competitively inhibits the activation of plasminogen to plasmin by binding to lysine‑binding sites on the plasminogen molecule. This blockade prevents the degradation of fibrin clots, thereby reducing fibrinolysis and promoting clot stability. The effect is dose‑dependent and occurs without directly affecting platelet function or the coagulation cascade. By preserving the fibrin matrix, the drug supports hemostasis in tissues where bleeding is excessive.

Side Effects

Tranexamic Acid may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset or queasiness.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools or increased bowel movements.
  • Headache: transient cranial discomfort.
  • Dizziness: feeling of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Thromboembolic events: formation of abnormal blood clots in veins or arteries.
  • Vision disturbances: blurred vision or visual field changes.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Hypotension: sudden drop in blood pressure, especially with rapid intravenous administration.

Precautions & Warnings

When prescribing Tranexamic Acid, certain precautions should be observed to ensure safe use.

  • Assess thrombotic risk: evaluate patient history for deep‑vein thrombosis, pulmonary embolism, or cardiovascular disease.
  • Monitor renal function: adjust use in patients with impaired kidney clearance.
  • Use with caution in pregnancy: consider potential risks and benefits before prescribing.
  • Avoid in active intravascular clotting: contraindicated in patients with ongoing thrombus formation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Tranexamic Acid can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Contraceptive hormonal agents: may increase risk of thrombosis when combined with estrogen‑containing products.
  • Direct factor Xa inhibitors (e.g., apixaban, rivaroxaban): heightened potential for clot formation.
  • Anticoagulants (warfarin, heparin): may reduce anticoagulant effect and alter INR.

Moderate Interactions (Monitor Closely)

  • Antiplatelet drugs (aspirin, clopidogrel): monitor for additive bleeding control or clotting changes.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): observe for gastrointestinal irritation.
  • CYP450 substrates: potential for altered metabolism, requiring dose adjustments.

Frequently Asked Questions

Nimra, containing tranexamic acid, is prescribed to manage excessive menstrual bleeding (menorrhagia), to reduce blood loss during surgical procedures, and to control acute hemorrhage resulting from traumatic injuries. By stabilizing clots, it helps patients maintain normal blood volume and reduces the need for transfusions in these clinical settings.

Tranexamic acid blocks the conversion of plasminogen to plasmin by binding to lysine‑binding sites on the plasminogen molecule. This inhibition prevents fibrin degradation, thereby preserving clot integrity and limiting excessive bleeding. The action is localized to the site of hemorrhage and does not directly affect platelet function or the coagulation cascade.

The dosage of Nimra is individualized by the prescribing clinician based on the specific indication, patient weight, renal function, and overall clinical assessment. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy in accordance with established treatment guidelines and the patient’s medical history.

Safety data for tranexamic acid in pregnancy and lactation are limited, and the drug should only be used when the potential benefit outweighs any possible risk to the fetus or infant. Prescribers typically evaluate maternal health, bleeding severity, and alternative options before deciding on therapy during pregnancy or while nursing.

To request Nimra, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Nimra’s active ingredient, tranexamic acid, is a widely used antifibrinolytic that offers oral administration and a well‑characterized safety profile. Compared with alternatives such as aminocaproic acid, tranexamic acid generally provides stronger inhibition of fibrinolysis, requires lower doses, and has a more predictable pharmacokinetic profile, making it a preferred choice in many surgical and obstetric settings.

Nimra should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use. Do not refrigerate or freeze the tablets, as temperature extremes may affect stability.

Nimra is supplied as an oral formulation that is taken by mouth with or without water, as directed by the prescribing clinician. The exact timing—such as before a surgical procedure or during a menstrual cycle—depends on the indication and the dosage schedule determined by the healthcare provider.

The most serious concerns involve the potential for thromboembolic events, such as deep‑vein thrombosis or pulmonary embolism, especially in patients with pre‑existing clotting disorders. Rare but severe reactions can include visual disturbances, severe allergic responses, and sudden hypotension when administered rapidly intravenously. Prompt medical attention is required if these symptoms arise.

Nimra is contraindicated in individuals with active intravascular clot formation, a known hypersensitivity to tranexamic acid, or those who have experienced previous thrombotic complications without adequate anticoagulation. Patients with severe renal impairment may also require alternative therapy, and the decision should be made by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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