Product image of Nintedanib supplied by GNH India

Nintedanib

Active Ingredient:
Nintedanib
Origin:
EU

Nintedanib

Nintedanib, the active ingredient in Nintedanib, is a tyrosine kinase inhibitor presented as an oral formulation for oral use. It is indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and non‑small cell lung cancer in appropriate patients.

GNH India supplies Nintedanib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and clinical use across multiple regions.

Manufacturer / TM Owner

1 A Pharma Gmbh

1
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Indications & Clinical Uses

Nintedanib is used to target fibrotic processes and tumor growth in several serious lung‑related conditions.

  • Idiopathic pulmonary fibrosis: slows disease progression and reduces decline in lung function.
  • Systemic sclerosis‑associated interstitial lung disease: improves forced vital capacity and stabilizes respiratory symptoms.
  • Non‑small cell lung cancer: used in combination therapy to inhibit tumor angiogenesis and growth.

How It Works

  • Nintedanib inhibits multiple receptor tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR 1‑3), platelet‑derived growth factor receptors (PDGFR α/β) and fibroblast growth factor receptors (FGFR 1‑3). By blocking these pathways, it reduces fibroblast proliferation, migration and transformation, and suppresses angiogenesis, thereby limiting fibrotic tissue formation and tumor vascular supply.

Side Effects

Nintedanib may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Diarrhea: frequent loose stools, often mild to moderate.
  • Nausea: feeling of sickness, may be accompanied by vomiting.
  • Abdominal pain: discomfort or cramps in

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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