Product image of Nintedanib Arrow (Nintedanib) supplied by GNH India

Nintedanib Arrow

Active Ingredient:
Nintedanib
Origin:
EU

Nintedanib Arrow (Nintedanib)

Nintedanib, the active ingredient in Nintedanib Arrow, is a tyrosine kinase inhibitor presented as an oral tablet for oral use. It treats idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and non‑small cell lung cancer when given with docetaxel.
GNH India supplies Nintedanib Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

1
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Indications & Clinical Uses

Nintedanib is indicated for fibrotic lung disorders and selected oncology regimens.

  • Idiopathic pulmonary fibrosis: slows disease progression and reduces decline in lung function.
  • Systemic sclerosis‑associated interstitial lung disease: helps preserve lung capacity and delay worsening.
  • Non‑small cell lung cancer (in combination with docetaxel): improves overall survival and progression‑free survival.

How It Works

  • Nintedanib inhibits multiple receptor tyrosine kinases—including VEGFR, PDGFR, and FGFR—thereby blocking signaling pathways that drive fibroblast proliferation, angiogenesis, and pathological tissue remodeling. This multi‑target inhibition reduces fibrotic activity in the lung and impairs tumor‑related vascular support, contributing to its antifibrotic and antineoplastic effects.

Side Effects

Nintedanib may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Decreased appetite
  • Elevated liver enzymes
  • Abdominal pain

Serious or Rare Side Effects

  • Hepatic failure or severe liver injury
  • Major bleeding events
  • Gastrointestinal perforation
  • Severe hypertension or arterial thromboembolism
  • Interstitial lung disease exacerbation

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor liver function: obtain baseline and periodic hepatic enzyme tests.
  • Assess bleeding risk: avoid in patients with active hemorrhage or uncontrolled anticoagulation.
  • Evaluate cardiovascular status: monitor blood pressure regularly during treatment.
  • Contraindicated in severe hepatic impairment: do not use in patients with Child‑Pugh C liver disease.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Nintedanib can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase nintedanib exposure.
  • Anticoagulants (e.g., warfarin): heightened risk of bleeding.
  • P‑glycoprotein inhibitors (e.g., itraconazole): may raise plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin): may lower drug levels and effectiveness.
  • Antiplatelet agents (e.g., aspirin): monitor for signs of bleeding.
  • Diuretics: watch for dehydration and renal function changes.

Frequently Asked Questions

Nintedanib Arrow is prescribed for idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and for non‑small cell lung cancer when used together with docetaxel. In each case the drug targets pathways that contribute to fibrosis or tumor‑related angiogenesis, helping to slow disease progression.

Nintedanib blocks several receptor tyrosine kinases—VEGFR, PDGFR, and FGFR—thereby inhibiting signals that promote fibroblast growth, new blood‑vessel formation, and tissue remodeling. This multi‑target inhibition reduces fibrotic tissue buildup in the lungs and limits the vascular support that tumors need to grow.

The specific dose and dosing schedule for Nintedanib Arrow are determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and other individual factors. Healthcare professionals should follow the product label and local prescribing guidelines.

The safety of Nintedanib Arrow in pregnancy and lactation has not been established. It is classified as pregnancy category unknown, and the drug should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician before using the medication.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Nintedanib differs from other antifibrotics such as pirfenidone by targeting a broader range of tyrosine kinases, which may provide additional benefit in certain fibrotic pathways. Clinical trials have shown comparable efficacy in slowing lung‑function decline, but the side‑effect profile and drug‑interaction potential vary, so choice of therapy should be individualized.

Nintedanib Arrow should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the product out of direct sunlight and away from sources of humidity.

Nintedanib Arrow is taken orally, usually as a whole tablet swallowed with water. The medication is typically taken with food to reduce gastrointestinal discomfort, but patients should follow the specific instructions provided by their healthcare professional.

Serious risks include severe liver injury, major bleeding events, gastrointestinal perforation, and significant hypertension or arterial thromboembolism. Patients should be monitored regularly for signs of these complications, and therapy should be discontinued if any life‑threatening adverse event occurs.

Nintedanib Arrow is contraindicated in patients with severe hepatic impairment (Child‑Pugh C), active uncontrolled bleeding, or known hypersensitivity to nintedanib or any of the tablet excipients. Caution is also advised for individuals with significant cardiovascular disease or a history of gastrointestinal ulcers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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