Product image of Nintedanib Eignapharma (Nintedanib) supplied by GNH India

Nintedanib Eignapharma

Active Ingredient:
Nintedanib
Origin:
EU

Nintedanib Eignapharma (Nintedanib)

Nintedanib, the active ingredient in Nintedanib Eignapharma, is a tyrosine kinase inhibitor presented as an oral dosage form for oral use. It is used to treat idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and certain forms of non‑small cell lung cancer in adult patients.

GNH India supplies Nintedanib Eignapharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eignapharma Slu

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Indications & Clinical Uses

  • Nintedanib is indicated for fibrotic lung disorders and selected oncologic settings, acting on pathways that drive fibroblast proliferation and tumor angiogenesis.
  • Idiopathic pulmonary fibrosis: slows disease progression and reduces decline in lung function.
  • Systemic sclerosis‑associated interstitial lung disease: helps preserve lung capacity and delay worsening.
  • Non‑small cell lung cancer (in combination therapy): contributes to inhibition of tumor growth and disease progression.

How It Works

  • Nintedanib inhibits multiple receptor tyrosine kinases—including vascular endothelial growth factor receptors (VEGFR 1‑3), fibroblast growth factor receptors (FGFR 1‑3), and platelet‑derived growth factor receptors (PDGFR‑α/β). By blocking these pathways, it reduces fibroblast activation, angiogenesis, and extracellular matrix deposition, thereby limiting fibrotic remodeling and tumor‑related vascular growth.

Side Effects

Nintedanib may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Decreased appetite
  • Elevated liver enzymes (ALT/AST)

Serious or Rare Side Effects

  • Severe hepatic injury or hepatitis
  • Major bleeding events
  • Cardiovascular complications (e.g., myocardial infarction)
  • Gastrointestinal perforation
  • Severe infections
  • Pulmonary hypertension

Precautions & Warnings

  • When prescribing Nintedanib, clinicians should consider several safety measures.
  • Monitor liver function: perform baseline and periodic ALT/AST assessments.
  • Assess bleeding risk: evaluate concomitant anticoagulant or antiplatelet therapy.
  • Evaluate cardiovascular status: watch for hypertension or ischemic events.
  • Avoid use in severe hepatic impairment: contraindicated in patients with Child‑Pugh C.
  • Pregnancy and lactation: use only if potential benefit justifies risk; discuss with patient.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Nintedanib can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may markedly increase nintedanib exposure.
  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): heightened risk of bleeding.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic levels.
  • P‑gp inhibitors (e.g., verapamil): modestly increase plasma concentrations.
  • Diuretics: may exacerbate dehydration and renal impairment.
  • Antihypertensives: monitor blood pressure as nintedanib can cause hypertension.

Frequently Asked Questions

Nintedanib Eignapharma is prescribed for idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and for certain cases of non‑small cell lung cancer when used in combination with other anticancer agents. It works by targeting pathways that drive fibrosis and tumor angiogenesis.

Nintedanib blocks several receptor tyrosine kinases—VEGFR, FGFR, and PDGFR—thereby reducing fibroblast proliferation, new blood‑vessel formation, and the deposition of scar tissue. This dual antifibrotic and anti‑angiogenic activity helps slow disease progression in the lungs and can limit tumor growth.

The specific dose and dosing schedule of Nintedanib Eignapharma are determined by the prescribing physician based on the patient’s condition, weight, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Nintedanib in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To request Nintedanib Eignapharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nintedanib differs from other antifibrotics such as pirfenidone by targeting a broader range of tyrosine kinases (VEGFR, FGFR, PDGFR). This broader inhibition may provide additional benefit in certain fibrotic pathways, but the safety profile and tolerability can vary. Choice of therapy should be individualized by the treating physician.

Nintedanib Eignapharma should be stored at temperatures below 25 °C, in the original packaging, protected from moisture and direct light. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Nintedanib Eignapharma is taken orally, usually with food to reduce gastrointestinal discomfort. The tablets (or capsules, depending on the specific presentation) are swallowed whole with a glass of water. Patients should follow the dosing instructions provided by their prescriber.

The most serious risks include severe liver injury, major bleeding events, cardiovascular complications such as myocardial infarction, gastrointestinal perforation, and rare cases of pulmonary hypertension. Patients should be monitored regularly for signs of these adverse events and report any concerning symptoms promptly.

Nintedanib is contraindicated in patients with severe hepatic impairment (Child‑Pugh C), those with known hypersensitivity to the drug or its excipients, and individuals who are currently experiencing significant bleeding or have uncontrolled hypertension. The prescriber should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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