Product image of Nintedanib Teva (Nintedanib) supplied by GNH India

Nintedanib Teva

Active Ingredient:
Nintedanib
Origin:
EU

Nintedanib Teva (Nintedanib)

Nintedanib, the active ingredient in Nintedanib Teva, is a tyrosine kinase inhibitor presented as an oral formulation for oral use. It treats idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and non‑small cell lung cancer in appropriate patients.

GNH India supplies Nintedanib Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Arzneimittel Vertriebs-Gmbh

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Indications & Clinical Uses

Nintedanib is used in fibrotic lung disorders and certain cancers, targeting pathways that drive fibroblast activity and tumor angiogenesis.

  • Idiopathic pulmonary fibrosis: slows decline in lung function and reduces disease progression.
  • Systemic sclerosis‑associated interstitial lung disease: improves forced vital capacity and stabilises respiratory status.
  • Non‑small cell lung cancer (with appropriate companion therapy): inhibits tumour growth and angiogenesis, contributing to disease control.

How It Works

  • Nintedanib inhibits multiple receptor tyrosine kinases—including VEGFR, FGFR and PDGFR—thereby reducing fibroblast proliferation, migration and extracellular matrix deposition. The same anti‑angiogenic activity limits tumour vascularisation, contributing to its antifibrotic and anticancer effects when administered orally.

Side Effects

Nintedanib may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea
  • Diarrhoea
  • Abdominal pain
  • Decreased appetite
  • Vomiting
  • Elevated liver enzymes (ALT/AST)

Serious or Rare Side Effects

  • Severe liver injury
  • Bleeding events
  • Arterial thromboembolic episodes
  • Hypertension
  • Gastrointestinal perforation
  • Severe infections

Precautions & Warnings

Before initiating therapy, clinicians should assess several safety parameters.

  • Liver function monitoring: check ALT/AST before and during treatment.
  • Bleeding risk: avoid concomitant anticoagulants unless clearly indicated.
  • Cardiovascular assessment: evaluate for hypertension and arterial events.
  • Gastrointestinal health: monitor for signs of perforation or severe diarrhoea.
  • Pregnancy and lactation: use only if benefits outweigh potential risks; safety not established.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture.

Avoid Interactions

Nintedanib can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase nintedanib exposure.
  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): heightened bleeding risk.
  • P‑glycoprotein inhibitors (e.g., verapamil): may raise plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Antihypertensives: may require dose adjustment due to blood‑pressure changes.
  • Diuretics: monitor electrolytes if combined with gastrointestinal fluid loss.

Frequently Asked Questions

Nintedanib Teva is prescribed for idiopathic pulmonary fibrosis, systemic sclerosis‑associated interstitial lung disease, and for certain cases of non‑small cell lung cancer. In each condition it aims to slow disease progression by targeting cellular pathways involved in fibrosis and tumour angiogenesis.

Nintedanib blocks multiple receptor tyrosine kinases such as VEGFR, FGFR and PDGFR. By inhibiting these signals it reduces fibroblast activity, extracellular‑matrix deposition and new blood‑vessel formation, which together help limit fibrotic tissue growth and tumour vascularisation.

The specific dose and dosing schedule of Nintedanib Teva are determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and other individual factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for Nintedanib during pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women of child‑bearing potential should use effective contraception during treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative for idiopathic pulmonary fibrosis is pirfenidone, another antifibrotic agent. While both slow disease progression, Nintedanib targets a broader range of tyrosine‑kinase pathways and also has approved use in certain cancers, whereas pirfenidone’s activity is limited to fibrotic lung disease.

Nintedanib Teva should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Nintedanib Teva is taken orally, usually as a capsule or tablet, with food or as directed by the prescribing physician. Patients should swallow the dose whole with a full glass of water and not crush or split the dosage form unless instructed.

Serious risks include severe liver injury, significant bleeding, arterial thromboembolic events, hypertension, gastrointestinal perforation and serious infections. Patients should report any signs of abdominal pain, unusual bruising, yellowing of the skin or eyes, or sudden severe headaches to their healthcare provider promptly.

Nintedanib is contraindicated in patients with known hypersensitivity to the drug or any of its excipients, in those with active severe hepatic impairment, and in individuals with uncontrolled bleeding disorders. Caution is also advised for patients with recent major surgery or gastrointestinal ulceration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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