Product image of Nipas (Acetylsalicylic Acid) supplied by GNH India

Nipas

Active Ingredient:
Acetylsalicylic Acid
Origin:
EU

Nipas (Acetylsalicylic Acid)

Acetylsalicylic Acid, the active ingredient in Nipas, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is employed to relieve pain, reduce fever, diminish inflammation, and provide cardiovascular prophylaxis in appropriate adult patients.

GNH India supplies Nipas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable logistics for bulk and small‑volume orders. The company ensures product integrity through rigorous testing and temperature‑controlled shipping where required.

Manufacturer / TM Owner

Farmaceutyczna Spoldzielnia Pracy Galena

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Indications & Clinical Uses

  • Acetylsalicylic Acid is used in several clinical contexts that involve pain, fever, inflammation, or platelet inhibition.
  • Pain: alleviates mild to moderate pain such as headache or musculoskeletal discomfort.
  • Fever: reduces elevated body temperature in febrile states.
  • Inflammation: decreases inflammatory response in conditions like arthritis.
  • Cardiovascular prophylaxis: inhibits platelet aggregation to lower risk of myocardial infarction and stroke in at‑risk adults.

How It Works

  • Acetylsalicylic Acid irreversibly acetylates the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking conversion of arachidonic acid to prostaglandins and thromboxanes. The reduction in prostaglandins mediates analgesic, antipyretic and anti‑inflammatory effects, while decreased thromboxane A2 production impairs platelet aggregation, providing antithrombotic benefit. The acetylation is permanent for the lifespan of the platelet, and the drug’s systemic distribution allows it to reach inflamed tissues and vascular endothelium.

Side Effects

Acetylsalicylic Acid may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or heartburn.
  • Minor bleeding: easy bruising or nosebleeds.
  • Headache: transient headache episodes.
  • Skin irritation: mild rash or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or hemorrhage.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Reye syndrome: especially in children with viral illness.
  • Hepatic dysfunction: elevated liver enzymes.
  • Blood disorders: thrombocytopenia or agranulocytosis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • When prescribing or dispensing Acetylsalicylic Acid, several safety considerations should be observed.
  • Assess bleeding risk: evaluate history of ulcers, anticoagulant use or coagulopathy.
  • Avoid in active gastrointestinal ulcer: contraindicated in patients with current peptic ulcer disease.
  • Monitor renal function: NSAIDs can impair renal perfusion, especially in the elderly or dehydrated.
  • Caution in children with viral infections: risk of Reye syndrome warrants avoidance.
  • Use with caution alongside anticoagulants or antiplatelet agents: increased bleeding potential.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Acetylsalicylic Acid can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Corticosteroids: increased risk of ulceration and bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs): enhanced bleeding tendency.
  • Alcohol: synergistic gastric mucosal irritation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, diuretics): may reduce renal function.
  • Lithium: aspirin can increase lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.
  • Oral hypoglycemics: possible enhancement of hypoglycemic effect.
  • Allopurinol: may increase risk of hypersensitivity reactions.

Frequently Asked Questions

Nipas contains acetylsalicylic acid and is used to relieve mild to moderate pain, lower fever, reduce inflammation in conditions such as arthritis, and provide antithrombotic protection to lower the risk of heart attack or stroke in appropriate adult patients.

Acetylsalicylic acid irreversibly blocks the COX‑1 and COX‑2 enzymes, preventing the formation of prostaglandins that mediate pain, fever and inflammation, and reducing thromboxane A2 production, which limits platelet aggregation and provides cardiovascular benefit.

The dose of Nipas is individualized by the prescribing healthcare professional based on the specific indication, patient age, weight, renal function and any concomitant medications. No fixed regimen is provided here; the prescriber sets the appropriate dosage.

Safety data for acetylsalicylic acid in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by a qualified clinician. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To request Nipas, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nipas is a generic formulation of acetylsalicylic acid, the same active ingredient found in branded aspirin products. Its efficacy and safety profile are comparable to other NSAIDs, but it uniquely offers antiplatelet activity at low doses, which many non‑aspirin NSAIDs lack.

Nipas should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Nipas is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can lessen gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, Reye syndrome in children with viral infections, and rare blood disorders. Patients should seek immediate medical attention if they experience unexplained bruising, black stools, severe abdominal pain, or signs of an allergic reaction.

Nipas should be avoided in individuals with a known hypersensitivity to aspirin or other NSAIDs, active peptic ulcer disease, uncontrolled bleeding disorders, severe liver or kidney impairment, and in children or teenagers with viral infections due to the risk of Reye syndrome. Consultation with a clinician is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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