Niredil (Glyceryl Trinitrate)

Glyceryl trinitrate is metabolised to nitric oxide in vascular smooth muscle. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle and causes venous and arterial dilation. This reduces cardiac preload and afterload, lowering myocardial oxygen demand and alleviating ischaemic pain.

The specific dose and patch size are determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerance. The prescriber selects the appropriate strength and duration of therapy, and patients should follow the individualised instructions provided with the prescription.

Safety of glyceryl trinitrate in pregnancy and lactation has not been definitively established. It is classified as pregnancy category unknown, and use is generally reserved for situations where the potential benefit justifies any potential risk to the fetus or infant. Consultation with a healthcare professional is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Niredil. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Niredil delivers glyceryl trinitrate continuously through the skin, offering steady plasma levels and reducing the need for multiple oral doses. Compared with short‑acting oral nitrates, the patch provides more consistent symptom control and fewer peaks of hypotension, but it may cause more localized skin irritation. Other drug classes, such as beta‑blockers or calcium channel blockers, act via different mechanisms and are often used in combination.

Store at room temperature, preferably below 25 °C. Keep the patch in its original sealed packaging, protect it from moisture, direct sunlight and excessive heat. Do not store in a refrigerator or freezer, and keep it out of reach of children.

The patch is applied to a clean, dry, hair‑free area of the upper torso or upper arm. Remove the protective liner, press the adhesive side firmly onto the skin, and leave it in place for the prescribed duration, usually 12–24 hours. After removal, dispose of the used patch according to local regulations and rotate to a different site for the next application.

The most serious adverse reactions include severe hypotension, reflex tachycardia, and rare cases of methemoglobinemia. These events can lead to dizziness, fainting, or cardiovascular instability and require immediate medical attention. Patients should be educated to recognize symptoms and seek care promptly if they occur.

Niredil is contraindicated in patients with known hypersensitivity to glyceryl trinitrate or other organic nitrates, those with severe hypotension, and individuals who have recently used phosphodiesterase‑5 inhibitors such as sildenafil. It should also be used with caution in patients with elevated intracranial pressure or severe anemia. Consultation with a healthcare provider is required before initiating therapy.