Product image of Nirolex Febbre E Dolore Adulti (Paracetamol) supplied by GNH India

Nirolex Febbre E Dolore Adulti

Active Ingredient:
Paracetamol
Origin:
EU

Nirolex Febbre E Dolore Adulti (Paracetamol)

Paracetamol, the active ingredient in Nirolex Febbre E Dolore Adulti, is a Analgesic/Antipyretic presented as a rectal dosage form for rectal use. It treats fever and mild to moderate pain in adults.

GNH India supplies Nirolex Febbre E Dolore Adulti as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almus S.R.L.

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Indications & Clinical Uses

Paracetamol is an analgesic/antipyretic that reduces fever and alleviates mild to moderate pain.

  • Fever: lowers elevated body temperature.
  • Headache: relieves tension‑type headache.
  • Musculoskeletal pain: eases mild to moderate muscle or joint discomfort.
  • Dental pain: reduces pain after dental procedures.
  • Cold/flu symptoms: helps control fever and associated body aches.

How It Works

  • Paracetamol acts centrally by inhibiting the synthesis of prostaglandins in the brain, primarily through blockade of the cyclooxygenase (COX) pathway. This reduction in prostaglandin production diminishes the perception of pain and lowers the hypothalamic set‑point for temperature regulation, producing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Mild abdominal discomfort
  • Rash or mild skin irritation
  • Dizziness

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hepatotoxicity, especially with overdose or chronic use
  • Blood disorders including agranulocytosis
  • Anaphylactic reactions
  • Severe hypotension

Precautions & Warnings

Paracetamol should be used with attention to specific safety considerations.

  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Avoid alcohol: concurrent consumption may increase risk of liver injury.
  • Monitor dosage in elderly: reduced metabolic capacity may require lower doses.
  • Check for allergy: discontinue if rash or hypersensitivity develops.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Warfarin: may increase bleeding risk.
  • Alcohol: potentiates hepatotoxicity.
  • Carbamazepine: may reduce paracetamol efficacy.
  • Isoniazid: increased risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (e.g., phenytoin): may alter plasma levels.
  • Oral contraceptives: may reduce effectiveness.
  • Rifampicin: may increase metabolism, reducing analgesic effect.

Frequently Asked Questions

Nirolex Febbre E Dolore Adulti contains paracetamol and is used to reduce fever and relieve mild to moderate pain such as headache, muscle aches, dental discomfort, and other common aches in adults.

Paracetamol works by inhibiting central prostaglandin synthesis, which lowers the hypothalamic temperature set‑point and reduces the perception of pain, providing antipyretic and analgesic effects without strong peripheral anti‑inflammatory activity.

The appropriate dose is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and local guidelines. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety data for rectal paracetamol in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit profile for each individual; generally, paracetamol is considered the analgesic/antipyretic of choice when treatment is necessary, but professional guidance is essential.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Paracetamol offers effective fever reduction and pain relief with a lower risk of gastrointestinal irritation compared with non‑steroidal anti‑inflammatory drugs (NSAIDs). Unlike NSAIDs, it has minimal anti‑inflammatory activity but is preferred when bleeding risk or gastric side effects are concerns.

Store the product at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain stability and potency.

The medication is supplied for rectal administration. The appropriate suppository is inserted into the rectum according to the prescriber’s instructions, ensuring proper positioning for optimal absorption.

Serious risks include rare but severe skin reactions (e.g., Stevens‑Johnson syndrome), hepatotoxicity especially with overdose or chronic use, blood disorders such as agranulocytosis, and anaphylaxis. Patients should seek immediate medical attention if they notice any of these symptoms.

Individuals with known hypersensitivity to paracetamol, severe liver disease, or those taking medications that may cause dangerous interactions (e.g., certain anticoagulants, alcohol excess) should avoid this product unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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