Product image of Nisegal (Dexamethasone, Ciprofloxacin) supplied by GNH India

Nisegal

Active Ingredient:
Dexamethasone, Ciprofloxacin
Origin:
EU

Nisegal (Dexamethasone, Ciprofloxacin)

Dexamethasone and Ciprofloxacin, the active ingredients in Nisegal, are a corticosteroid and a fluoroquinolone antibiotic presented as a topical ear preparation for auricular use. They treat inflammatory and bacterial ear conditions such as otitis externa in adults and children.
GNH India supplies Nisegal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farma Group S.R.L.

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Indications & Clinical Uses

Nisegal combines a corticosteroid and a fluoroquinolone antibiotic to address inflammatory and bacterial processes in the ear.

  • Otitis externa: reduces inflammation and eliminates the causative bacteria, relieving pain and discharge.
  • Ear canal inflammation: alleviates swelling, itching and discomfort associated with non‑infectious irritation.
  • Bacterial ear infections: eradicates susceptible organisms and improves hearing-related symptoms.

How It Works

  • Dexamethasone binds to intracellular glucocorticoid receptors, modulating gene transcription and suppressing the release of inflammatory mediators such as prostaglandins and cytokines. Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, leading to bacterial cell death and resolution of infection.

Side Effects

Common Side Effects

  • Ear itching or mild burning sensation
  • Local irritation or redness of the ear canal
  • Transient hearing changes or muffled sound
  • Mild headache
  • Temporary tinnitus
  • Slight ear discharge

Serious or Rare Side Effects

  • Allergic reaction including anaphylaxis
  • Severe ototoxicity with persistent hearing loss
  • Tympanic membrane perforation
  • Secondary fungal or bacterial infection
  • Systemic fluoroquinolone effects such as tendon rupture
  • Vision disturbances or photosensitivity

Precautions & Warnings

Before using Nisegal, consider the following precautions:

  • Assess for tympanic membrane perforation: avoid use if perforation is present.
  • Confirm bacterial etiology: reserve for confirmed or strongly suspected bacterial ear infections.
  • Hypersensitivity: do not use in patients with known allergy to corticosteroids or fluoroquinolones.
  • Monitor intra‑ocular pressure: caution in patients with glaucoma.
  • Pediatric use: observe for systemic absorption signs, especially with prolonged therapy.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Nisegal may interact with other medicines as follows:

Major Interactions (Avoid)

  • Systemic corticosteroids: increased risk of immunosuppression.
  • Systemic fluoroquinolones: heightened risk of tendon rupture.
  • Anticholinergic eye drops: may reduce local efficacy.
  • Live vaccines: possible reduced immune response.
  • NSAIDs: increased risk of ear bleeding.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may reduce ciprofloxacin absorption.
  • Warfarin: potential enhancement of anticoagulant effect.
  • Diuretics: possible electrolyte disturbances.
  • Oral contraceptives: may experience reduced effectiveness.
  • Diabetes medications: corticosteroid component may raise blood glucose levels.

Frequently Asked Questions

Nisegal is indicated for the treatment of otitis externa, ear canal inflammation, and bacterial ear infections. It combines anti‑inflammatory and antibacterial actions to relieve pain, reduce swelling, and eradicate pathogenic bacteria in the external auditory canal.

Dexamethasone acts as a glucocorticoid receptor agonist, suppressing inflammatory mediators and reducing swelling. Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and leading to bacterial cell death. Together they provide both anti‑inflammatory and antibacterial effects.

The dosage of Nisegal is determined by the prescribing healthcare professional based on the severity of the ear condition, patient age, and clinical response. Patients should follow the prescriber’s instructions and the product label carefully.

Safety data for Nisegal in pregnancy and lactation are limited. The decision to use it should be made by a qualified healthcare provider after weighing potential benefits against possible risks to the mother and infant.

To order Nisegal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent ear antibiotics, Nisegal offers a dual mechanism by adding a corticosteroid to the fluoroquinolone. This combination can provide faster symptom relief by reducing inflammation while simultaneously treating the bacterial infection, which may be advantageous in mixed inflammatory‑infectious conditions.

Nisegal should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing to maintain product stability.

Nisegal is applied topically to the ear canal. The prescribed number of drops is placed into the affected ear(s) as directed by the healthcare professional, typically after gently cleaning the outer ear and positioning the head to allow the medication to coat the canal.

Serious risks include allergic reactions such as anaphylaxis, severe ototoxicity leading to permanent hearing loss, tympanic membrane perforation, and systemic fluoroquinolone effects like tendon rupture. Patients should seek immediate medical attention if they experience severe pain, sudden hearing changes, or signs of an allergic reaction.

Nisegal should not be used by individuals with known hypersensitivity to dexamethasone, ciprofloxacin, or any component of the formulation, and it is contraindicated in ears with a confirmed perforated tympanic membrane unless specifically advised by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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