Niteherb (Valerianae Radix Dry Extract)

• Niteherb, a valerian root extract, acts on the GABAergic system to address sleep‑related conditions and mild anxiety.
• Insomnia: helps reduce time needed to fall asleep and improves overall sleep continuity.
• Sleep disturbances: supports more stable sleep patterns and reduces nighttime awakenings.
• Mild anxiety: contributes to a calming effect that may lessen everyday nervous tension.

• Valerianae Radix Dry Extract modulates GABAergic neurotransmission by enhancing the activity of the inhibitory neurotransmitter GABA. The extract interacts with GABA‑A receptor sites, increasing chloride ion influx and promoting neuronal hyperpolarisation, which leads to reduced central nervous system excitability and a calming effect that facilitates sleep onset and relaxation.

Valerian root extract is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

• Headache: mild to moderate discomfort often resolving without intervention.
• Dizziness: transient light‑headedness, especially when standing quickly.
• Gastrointestinal upset: nausea or mild stomach discomfort.
• Dry mouth: reduced salivation during use.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Hepatic dysfunction: abnormal liver enzyme levels, requiring medical evaluation.
• Severe dizziness or fainting: may indicate excessive central nervous system depression.

• When considering Niteherb, several safety measures should be observed.
• Adults only: intended for use by adult patients; pediatric use is not established.
• Allergy check: avoid if known hypersensitivity to valerian or related plants.
• CNS depressant caution: concurrent use with alcohol, benzodiazepines, or other sedatives may increase drowsiness.
• Driving and machinery: refrain from operating vehicles or heavy equipment until individual response is known.
• Pregnancy and lactation: safety has not been established; consult a healthcare professional before use.
• Store at ambient temperature: keep the product in its original container, protect from moisture and direct sunlight.

Valerian extract can influence the activity of other central nervous system agents.

Major Interactions (Avoid)

• Alcohol or benzodiazepines: combined use may cause excessive sedation and respiratory depression.
• Barbiturates: concurrent administration can potentiate CNS depressant effects.

Moderate Interactions (Monitor Closely)

• Antihistamines: may increase drowsiness, requiring dose adjustment.
• Antidepressants (SSRIs, SNRIs): monitor for enhanced sedation or serotonin syndrome signs.
• Antihypertensives: possible additive blood‑pressure‑lowering effect, observe blood pressure regularly.