Product image of Nitoman (Tetrabenazine) supplied by GNH India

Nitoman

Active Ingredient:
Tetrabenazine
Origin:
EU

Nitoman (Tetrabenazine)

Tetrabenazine, the active ingredient in Nitoman, is a VMAT2 inhibitor presented as an oral tablet for oral use. It treats Huntington's disease chorea, tardive dyskinesia and other hyperkinetic movement disorders in appropriate patients.

GNH India supplies Nitoman as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Nitoman, a VMAT2 inhibitor, is used to manage hyperkinetic movement disorders.

  • Huntington's disease chorea: reduces involuntary choreiform movements.
  • Tardive dyskinesia: alleviates persistent dyskinetic movements caused by long‑term antipsychotic use.
  • Other hyperkinetic movement disorders: improves motor control in various dopamine‑mediated conditions.

How It Works

  • Tetrabenazine reversibly inhibits vesicular monoamine transporter 2 (VMAT2) in presynaptic neurons, preventing the uptake of monoamines such as dopamine into synaptic vesicles. This leads to reduced cytoplasmic storage and release of dopamine, thereby decreasing excessive dopaminergic stimulation that underlies hyperkinetic movement disorders.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Fatigue: feeling of tiredness or reduced energy.
  • Dizziness: transient light‑headedness, especially when standing.
  • Depression: mood changes that may require monitoring.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of suicidal ideation or behavior.
  • Severe depression: marked depressive episodes requiring immediate attention.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.
  • Hepatic injury: signs of liver dysfunction such as jaundice.
  • Cardiac arrhythmia: irregular heart rhythms that may need cardiac evaluation.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor mood: watch for signs of depression or suicidal ideation.
  • Hepatic function: assess liver enzymes, especially in patients with known liver disease.
  • Renal impairment: adjust dosing in severe renal dysfunction.
  • Concomitant CNS depressants: use with caution as additive sedation may occur.
  • Discontinuation: avoid abrupt cessation; taper under medical supervision.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Tetrabenazine may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • CNS depressants (e.g., benzodiazepines): enhanced sedation and respiratory depression.
  • Antidepressants (especially SSRIs): potential for serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible additive hypotensive effect.
  • CYP2D6 inhibitors (e.g., quinidine): increased tetrabenazine plasma concentrations.

Frequently Asked Questions

Nitoman contains tetrabenazine, which is prescribed for Huntington's disease chorea, tardive dyskinesia, and other hyperkinetic movement disorders where excessive dopamine activity causes involuntary movements.

Tetrabenazine blocks the vesicular monoamine transporter 2 (VMAT2), reducing the storage and release of dopamine and other monoamines from nerve terminals. This depletion lowers dopaminergic stimulation that drives abnormal, involuntary movements.

The appropriate dose of Nitoman is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. Dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for tetrabenazine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Nitoman, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nitoman (tetrabenazine) is a VMAT2 inhibitor, whereas many alternative agents, such as antipsychotics, act by dopamine receptor blockade. Tetrabenazine directly reduces dopamine storage, offering a distinct mechanism that can be effective when receptor‑blocking drugs are insufficient or cause intolerable side effects.

Nitoman should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain its stability.

Nitoman is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact schedule and timing should follow the healthcare professional’s guidance.

Serious risks include the development of suicidal thoughts or behaviors, severe depression, neuroleptic malignant syndrome, significant liver injury, and cardiac arrhythmias. Patients should be monitored closely for any of these adverse events.

Nitoman is contraindicated in patients with known hypersensitivity to tetrabenazine or any of its excipients, and it should be used with caution in individuals with severe hepatic impairment, uncontrolled depression, or a history of suicidal behavior.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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