Product image of Nitrazepam Richter (Nitrazepam) supplied by GNH India

Nitrazepam Richter

Active Ingredient:
Nitrazepam
Origin:
EU

Nitrazepam Richter (Nitrazepam)

Nitrazepam, the active ingredient in Nitrazepam Richter, is a benzodiazepine presented as a tablet for oral use. It is prescribed for insomnia, anxiety disorders and seizure disorders in adult patients.

GNH India supplies Nitrazepam Richter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter România S.A.

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Indications & Clinical Uses

  • Nitrazepam belongs to the benzodiazepine class and acts on the central nervous system to modulate GABA activity, making it useful for several neuro‑psychiatric conditions.
  • Insomnia: helps initiate and maintain sleep in patients with difficulty sleeping.
  • Anxiety disorders: reduces excessive worry and tension.
  • Seizure disorders: provides adjunctive control of certain seizure types.

How It Works

  • Nitrazepam binds to the benzodiazepine site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the frequency of chloride channel opening in response to GABA, increasing neuronal inhibition and producing sedative, anxiolytic, anticonvulsant, and muscle‑relaxant effects.

Side Effects

Nitrazepam may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Dizziness
  • Impaired coordination
  • Memory impairment
  • Headache

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Paradoxical reactions such as agitation
  • Suicidal ideation or behavior
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Dependence or withdrawal syndrome

Precautions & Warnings

  • When prescribing nitrazepam, several safety considerations should be observed.
  • Assess renal and hepatic function: adjust use if impairment is present.
  • Avoid abrupt discontinuation: taper dose to prevent withdrawal.
  • Use caution in elderly patients: increased sensitivity to sedation and falls.
  • Avoid concomitant alcohol or CNS depressants: risk of additive sedation.
  • Monitor for depression or suicidal thoughts: especially during early treatment.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nitrazepam can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other CNS depressants (opioids, barbiturates, alcohol): may cause profound sedation or respiratory depression.
  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole): increase nitrazepam plasma levels.
  • Concurrent benzodiazepines: risk of excessive sedation and dependence.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampin, carbamazepine): may reduce therapeutic effect.
  • Selective serotonin reuptake inhibitors (SSRIs): may enhance central nervous system depression.
  • Antihistamines: can increase drowsiness.
  • Antiepileptic drugs (phenytoin): may alter seizure control.
  • Antihypertensives: additive hypotensive effect possible.

Frequently Asked Questions

Nitrazepam Richter is used to manage insomnia, to alleviate anxiety disorders, and as an adjunctive therapy for certain seizure disorders. It works by enhancing the inhibitory action of GABA in the brain, helping to promote sleep, reduce excessive worry, and control seizure activity.

Nitrazepam binds to the benzodiazepine site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This increases the frequency of chloride channel opening when GABA binds, leading to greater neuronal inhibition and producing sedative, anxiolytic, anticonvulsant, and muscle‑relaxant effects.

The appropriate dose of Nitrazepam Richter is determined by the prescribing healthcare professional based on the individual’s medical condition, age, response to therapy, and other factors. Patients should follow the prescriber’s instructions and never adjust the dose on their own.

Safety data for nitrazepam in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To order Nitrazepam Richter, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrazepam shares the core mechanism of GABA‑A modulation with other benzodiazepines but has a relatively long half‑life, which can provide sustained therapeutic effect for insomnia and anxiety. Compared with shorter‑acting agents, it may have a higher risk of next‑day sedation but offers less frequent dosing.

Nitrazepam Richter should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain its stability and potency throughout its shelf life.

Nitrazepam Richter is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water and follow the dosing schedule provided by the healthcare professional.

Serious risks include respiratory depression, severe hypotension, paradoxical reactions such as agitation or aggression, suicidal thoughts or behavior, severe skin reactions, and the potential for dependence, tolerance and withdrawal after prolonged use.

Nitrazepam Richter should be avoided in individuals with known hypersensitivity to nitrazepam or other benzodiazepines, those with severe respiratory insufficiency, acute narrow‑angle glaucoma, or severe hepatic impairment. Caution is also advised for patients with a history of substance abuse or severe depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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