Product image of Nitrendipine Viatris (Nitrendipine) supplied by GNH India

Nitrendipine Viatris

Active Ingredient:
Nitrendipine
Origin:
EU

Nitrendipine Viatris (Nitrendipine)

Nitrendipine, the active ingredient in Nitrendipine Viatris, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by lowering blood pressure.
GNH India supplies Nitrendipine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Nitrendipine is a dihydropyridine calcium‑channel blocker used in the management of arterial hypertension.

  • Hypertension: reduces peripheral vascular resistance and lowers systolic and diastolic blood pressure, helping to achieve target blood‑pressure goals.

How It Works

  • Nitrendipine selectively inhibits L‑type calcium channels in vascular smooth‑muscle cells, decreasing calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation, reduced systemic vascular resistance, and consequently lower arterial blood pressure.

Side Effects

Adverse reactions may occur with nitrendipine therapy.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: warm sensation and redness, especially after the first doses.
  • Peripheral edema: swelling of ankles or lower legs.
  • Dizziness or light‑headedness, particularly when standing quickly.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that may cause fainting.
  • Myocardial infarction: rare but possible in patients with pre‑existing coronary disease.
  • Cardiac arrhythmias: irregular heart rhythms requiring medical attention.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Angioedema: swelling of face, lips, or throat.

Precautions & Warnings

Before initiating nitrendipine, consider the following precautions.

  • Blood pressure monitoring: check baseline and regularly adjust therapy.
  • Concomitant antihypertensives: avoid excessive hypotension when combined with other agents.
  • Hepatic impairment: dose may need adjustment; monitor liver function.
  • Elderly patients: start at lower doses and monitor for dizziness.
  • CYP3A4 inhibitors: avoid strong inhibitors that can increase plasma levels.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nitrendipine may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise nitrendipine concentrations.
  • Other calcium‑channel blockers (e.g., amlodipine, felodipine): additive vasodilatory effect.
  • Grapefruit juice: can increase drug exposure and risk of hypotension.
  • Concurrent antihypertensives (e.g., ACE inhibitors, beta‑blockers): may cause excessive blood‑pressure fall.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance electrolyte shifts and orthostatic changes.

  • Beta‑blockers: may mask reflex tachycardia.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can attenuate antihypertensive response.

Frequently Asked Questions

Nitrendipine Viatris is prescribed to manage hypertension. By lowering systemic vascular resistance, it helps patients achieve and maintain target blood‑pressure levels, reducing the risk of cardiovascular complications associated with high blood pressure.

Nitrendipine blocks L‑type calcium channels in arterial smooth‑muscle cells, preventing calcium entry. This relaxation of vascular smooth muscle produces vasodilation, which decreases peripheral resistance and ultimately lowers arterial blood pressure.

The appropriate dose of nitrendipine is determined by the prescribing clinician based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s specific instructions.

Safety data for nitrendipine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified health‑care professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrendipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent arterial vasodilation. Compared with agents such as ACE inhibitors or beta‑blockers, it primarily reduces peripheral resistance rather than affecting heart rate or renin‑angiotensin activity, making it useful as monotherapy or in combination regimens.

Store tablets at room temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Nitrendipine is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable plasma levels. Swallow tablets whole; do not crush or chew.

Serious adverse events include severe hypotension, myocardial infarction, cardiac arrhythmias, hepatic dysfunction, and rare allergic reactions such as anaphylaxis or angioedema. Patients should seek immediate medical attention if they experience chest pain, fainting, rapid heartbeat, jaundice, or swelling of the face or throat.

Nitrendipine is contraindicated in individuals with known hypersensitivity to the drug or any dihydropyridine calcium‑channel blocker, and in patients with severe aortic stenosis or cardiogenic shock. Caution is also advised for those with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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