Product image of Nitriderm Tts (Glyceryl Trinitrate) supplied by GNH India

Nitriderm Tts

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitriderm Tts (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitriderm Tts, is an organic nitrate presented as a transdermal patch for transdermal use. It treats angina pectoris and is used in patients with chronic stable angina.

GNH India supplies Nitriderm Tts as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz

1
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Indications & Clinical Uses

  • Nitriderm Tts, containing glyceryl trinitrate, is used in the anti‑anginal pathway to prevent myocardial ischemia.
  • Prophylaxis of angina pectoris: reduces the frequency of angina attacks.
  • Management of chronic stable angina: improves exercise tolerance and reduces symptom burden.
  • Prevention of exertional angina: provides sustained nitrate delivery during physical activity.

How It Works

  • Glyceryl trinitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of smooth muscle, vasodilation of coronary and peripheral vessels, and a reduction in myocardial oxygen demand, thereby alleviating angina.

Side Effects

Adverse reactions may occur with any nitrate therapy.

Common Side Effects

  • Headache: often transient and dose‑related.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness: due to blood pressure lowering.
  • Hypotension: especially on standing.
  • Skin irritation at the patch site: erythema or itching.
  • Tachycardia: reflex increase in heart rate.

Serious or Rare Side Effects

  • Severe hypotension: can lead to syncope.
  • Syncope: sudden loss of consciousness.
  • Myocardial infarction: rare but reported.
  • Severe allergic reaction: including rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: extremely rare skin reaction.

Precautions & Warnings

  • Before prescribing Nitriderm Tts, clinicians should consider several safety measures.
  • Dose titration: start with the lowest patch strength and adjust based on response.
  • Blood pressure monitoring: check for hypotension, especially when changing position.
  • Concomitant nitrate therapy: avoid combined use to prevent additive vasodilation.
  • Use with caution in patients with recent myocardial infarction or severe anemia.
  • Avoid in patients with known hypersensitivity to organic nitrates.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nitriderm Tts can interact with several drug classes, requiring attention to avoid adverse events.

Major Interactions (Avoid)

  • Sildenafil and other PDE5 inhibitors: may cause profound hypotension.
  • Other organic nitrates: additive vasodilatory effect leading to severe blood pressure drop.
  • Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may enhance blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • Alcohol: can increase vasodilatory effect and dizziness.
  • Diuretics: may potentiate hypotensive response.
  • Certain antifungal agents (e.g., ketoconazole): may increase nitrate levels.

Frequently Asked Questions

Nitriderm Tts is a prescription transdermal patch that delivers glyceryl trinitrate, an organic nitrate, to prevent angina pectoris attacks and to manage chronic stable angina by improving myocardial oxygen balance during daily activities.

Glyceryl trinitrate is converted to nitric oxide within vascular smooth muscle. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle, dilates coronary and peripheral vessels, and reduces the heart’s oxygen demand, thereby relieving angina.

The prescribed dose of Nitriderm Tts is determined by the treating physician based on the patient’s clinical condition, severity of angina, and response to therapy. The prescriber selects the appropriate patch strength and wear schedule.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Nitriderm Tts provides continuous nitrate delivery via a patch, offering more stable plasma levels than short‑acting oral nitrates. Compared with beta‑blockers or calcium‑channel blockers, it primarily reduces myocardial oxygen demand through vasodilation rather than heart‑rate control, making it useful as adjunct therapy.

Store the patches at room temperature, below 25 °C, in their original sealed packaging. Protect them from moisture, direct sunlight, and extreme temperatures to maintain patch integrity and drug potency.

The patch is applied to clean, dry, hair‑free skin on the upper torso or upper arm. The prescribed wear time (usually 12–24 hours) is followed, after which the patch is removed, disposed of safely, and a new patch is applied to a different site.

Serious risks include severe hypotension, syncope, myocardial infarction, and rare allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be educated to recognize signs of profound low blood pressure and seek immediate medical attention if they occur.

Nitriderm Tts should be avoided in individuals with known hypersensitivity to glyceryl trinitrate or other organic nitrates, in patients using phosphodiesterase‑5 inhibitors, and in those with severe hypotension or certain cardiovascular conditions where additional vasodilation is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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