Product image of Nitro "pohl" Infus Voor Perfusorpompsystemen (Glyceryl Trinitrate) supplied by GNH India

Nitro "pohl" Infus Voor Perfusorpompsystemen

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitro "pohl" Infus Voor Perfusorpompsystemen (Glyceryl Trinitrate)

Glyceryl Trinitrate, the active ingredient in Nitro "pohl" Infus Voor Perfusorpompsystemen, is a nitrate vasodilator presented as an intravenous infusion solution for intravenous use. It treats angina pectoris, acute heart failure and severe hypertension in patients who need rapid vasodilation.

GNH India supplies Nitro "pohl" Infus Voor Perfusorpompsystemen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G. Pohl-Boskamp Gmbh Co. Kg

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Indications & Clinical Uses

  • Nitro "pohl" Infus contains glyceryl trinitrate, a nitrate vasodilator that acts on the coronary and systemic circulation. It is employed in the following clinical situations:
  • Angina pectoris: provides rapid relief of chest pain by decreasing myocardial oxygen demand.
  • Acute heart failure: improves cardiac output by reducing preload and afterload.
  • Severe hypertension: lowers blood pressure promptly through systemic vasodilation.

How It Works

  • Glyceryl trinitrate releases nitric oxide within vascular smooth‑muscle cells, activating guanylate cyclase and increasing cyclic GMP levels. Elevated cGMP causes smooth‑muscle relaxation, producing dilation of veins and arteries, reducing venous return and arterial resistance, which together lower myocardial oxygen consumption and systemic blood pressure.

Side Effects

Glyceryl trinitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after infusion.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness: due to lowered blood pressure.
  • Hypotension: mild to moderate drop in blood pressure.
  • Tachycardia: compensatory increase in heart rate.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: profound drop in blood pressure leading to shock.
  • Methemoglobinemia: impaired oxygen delivery in blood.
  • Myocardial infarction: rare but possible in susceptible patients.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Syncope: sudden loss of consciousness.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

  • When using Nitro "pohl" Infus, several precautions should be observed to ensure patient safety.
  • Monitor blood pressure: check regularly during infusion to avoid excessive hypotension.
  • Avoid concomitant PDE5 inhibitors: co‑administration with sildenafil, tadalafil or similar agents can cause severe hypotension.
  • Use with caution in anemia: reduced oxygen‑carrying capacity may worsen tissue hypoxia.
  • Adjust dose in intracranial pressure: elevated pressure may be aggravated by vasodilation.
  • Contraindicated in severe aortic stenosis: fixed outflow obstruction can lead to cardiovascular collapse.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Glyceryl trinitrate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension.
  • Other nitrates or nitrovasodilators: additive blood‑pressure‑lowering effect.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance hypotensive effect.
  • Beta‑blockers: can mask tachycardia response to hypotension.
  • Diuretics or other antihypertensives: may require dose adjustment.

Frequently Asked Questions

Nitro "pohl" Infus Voor Perfusorpompsystemen is an intravenous infusion containing glyceryl trinitrate. It is used in hospital settings to manage angina pectoris, provide rapid hemodynamic support in acute heart failure, and lower blood pressure in cases of severe hypertension where quick vasodilation is required.

Glyceryl trinitrate acts as a nitric‑oxide donor. Once administered, it releases nitric oxide, which activates guanylate cyclase in vascular smooth‑muscle cells. This raises cyclic GMP levels, causing smooth‑muscle relaxation, venous pooling, reduced preload, arterial dilation, and ultimately a decrease in myocardial oxygen demand and systemic blood pressure.

The specific infusion rate and total dose of Nitro "pohl" Infus are determined by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Healthcare professionals adjust the infusion to achieve the desired hemodynamic effect while observing safety guidelines.

Safety data for glyceryl trinitrate during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with obstetric specialists.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Nitro "pohl" Infus delivers glyceryl trinitrate intravenously, offering rapid onset and precise titration, which can be advantageous over oral or sublingual nitrates such as isosorbide dinitrate. While both classes share the same mechanism, the IV formulation allows immediate blood‑pressure control in acute settings, whereas oral agents are suited for chronic management.

Store the infusion solution below 25 °C in its original packaging, protecting it from light and moisture. Avoid freezing or shaking the container. Ensure the product is kept in a secure, temperature‑controlled environment until it is prepared for administration.

The product is administered as an intravenous infusion, typically via a calibrated infusion pump or controlled drip set. Healthcare professionals connect the solution to a sterile IV line, set the prescribed infusion rate, and monitor the patient’s vital signs throughout the administration period.

Serious risks include profound hypotension that can lead to shock, methemoglobinemia which impairs oxygen delivery, myocardial infarction in susceptible individuals, severe allergic reactions such as anaphylaxis, syncope, and potentially life‑threatening cardiac arrhythmias. Continuous hemodynamic monitoring is essential.

Contraindications include patients with severe aortic stenosis, known hypersensitivity to nitrates, concurrent use of phosphodiesterase‑5 inhibitors, and those with uncontrolled hypotension. Caution is also advised for individuals with anemia, elevated intracranial pressure, or recent use of other potent vasodilators.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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