Product image of Nitrocine (Glyceryl Trinitrate) supplied by GNH India

Nitrocine

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrocine (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitrocine, is a nitrate vasodilator presented as an intravenous solution for intravenous use. It is employed to relieve acute angina, manage myocardial infarction adjunctively, treat acute heart failure, and address hypertensive emergencies in adult patients.

GNH India supplies Nitrocine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide with reliable quality and regulatory compliance. The company adheres to EU GMP standards and provides full documentation for import and distribution.

Manufacturer / TM Owner

Merus Labs Luxco Ii S.À R.L.

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Indications & Clinical Uses

Nitrocine (glyceryl trinitrate) acts as a nitrate vasodilator to relieve myocardial ischemia and lower vascular resistance.

  • Acute angina pectoris: rapid relief of chest pain by dilating coronary arteries.
  • Myocardial infarction (adjunct therapy): improves coronary blood flow during acute infarction.
  • Acute heart failure: reduces preload and afterload to support cardiac output.
  • Hypertensive emergencies: provides prompt vasodilation to lower severe blood pressure.

How It Works

  • Glyceryl trinitrate releases nitric oxide within vascular smooth muscle cells, activating guanylate cyclase and increasing cyclic GMP levels. Elevated cGMP leads to relaxation of smooth muscle, causing venous dilation (reducing preload) and arterial dilation (reducing afterload), thereby improving myocardial oxygen supply and decreasing cardiac workload.

Side Effects

Nitrocine may cause a range of adverse reactions, most of which are related to its vasodilatory action.

Common Side Effects

  • Headache: throbbing pain due to cerebral vasodilation.
  • Flushing: warmth and redness of the skin.
  • Hypotension: drop in blood pressure, especially with rapid infusion.
  • Tachycardia: compensatory increase in heart rate.
  • Dizziness or light‑headedness.
  • Nausea.

Serious or Rare Side Effects

  • Severe hypotension leading to syncope.
  • Paradoxical myocardial ischemia.
  • Methemoglobinemia.
  • Anaphylactoid or allergic reactions.
  • Persistent tachyarrhythmias.
  • Acute renal impairment in susceptible patients.

Precautions & Warnings

When using Nitrocine, clinicians should observe specific safety measures.

  • Cardiovascular monitoring: observe blood pressure and heart rate during infusion.
  • Concomitant phosphodiesterase‑5 inhibitors: avoid due to risk of profound hypotension.
  • Severe anemia or increased intracranial pressure: use with caution.
  • Known hypersensitivity to nitrates: contraindicated.
  • Pregnancy and lactation: assess risk–benefit; limited data available.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Nitrocine interacts with several drug classes that can modify its hemodynamic effects.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): may cause severe hypotension.
  • Other nitrates or nitrites: additive vasodilatory effect leading to dangerous blood pressure fall.
  • Potent antihypertensives (e.g., clonidine): risk of excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt compensatory tachycardia.
  • Calcium‑channel blockers: additive blood pressure reduction.
  • Diuretics: may enhance volume depletion and hypotension.
  • ACE inhibitors or ARBs: monitor for synergistic blood pressure lowering.

Frequently Asked Questions

Nitrocine contains glyceryl trinitrate, a nitrate vasodilator that is used in hospital settings to treat acute angina pectoris, serve as an adjunct in myocardial infarction, manage acute heart failure, and rapidly lower blood pressure in hypertensive emergencies.

Glyceryl trinitrate releases nitric oxide in vascular smooth muscle, activating guanylate cyclase and raising cyclic GMP levels. This cascade relaxes smooth muscle, producing venous and arterial dilation, which reduces cardiac preload and afterload and improves myocardial oxygen delivery.

The specific dose and infusion rate of Nitrocine are determined by the prescribing clinician based on the patient’s condition, response, and institutional protocols. Healthcare professionals set the appropriate regimen at the point of care.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. Clinicians should evaluate the potential benefits against possible risks before prescribing Nitrocine to pregnant or nursing patients.

To request Nitrocine, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and import documentation.

Nitrocine (glyceryl trinitrate) provides rapid, short‑acting vasodilation, making it suitable for acute settings, whereas oral nitrates or beta‑blockers offer longer‑term control. Its intravenous route allows precise titration, but it requires careful monitoring for hypotension and tachyphylaxis, unlike some oral agents.

Nitrocine should be stored below 25 °C, in its original packaging, protected from light and moisture. The solution must be kept in a secure, temperature‑controlled environment and inspected for particulate matter before use.

Nitrocine is supplied for intravenous administration. It is typically infused through a controlled infusion pump or syringe driver, allowing the clinician to adjust the rate according to the patient’s hemodynamic response.

The most serious risks include severe hypotension, reflex tachycardia, myocardial ischemia due to excessive vasodilation, and rare events such as methemoglobinemia or anaphylactoid reactions. Continuous monitoring is essential to detect and manage these complications promptly.

Nitrocine is contraindicated in patients with known hypersensitivity to nitrates, those who have taken phosphodiesterase‑5 inhibitors within the previous 24‑48 hours, and individuals with severe hypotension or uncompensated shock. Clinicians must assess each patient’s medical history before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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