Product image of Nitrocor (Glyceryl Trinitrate) supplied by GNH India

Nitrocor

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrocor (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitrocor, is a nitrate vasodilator presented as a sublingual tablet for sublingual use. It provides rapid relief of angina pectoris and is employed in patients with coronary artery disease to alleviate myocardial ischemia.

GNH India supplies Nitrocor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable cold‑chain logistics where required, ensuring product integrity from manufacturing to end‑user and timely delivery.

Manufacturer / TM Owner

Unifarma

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Indications & Clinical Uses

  • Nitrocor (glyceryl trinitrate) is a nitrate vasodilator used in the management of coronary artery disease and related angina syndromes.
  • Acute angina pectoris: provides rapid relief of chest pain during an attack.
  • Prophylaxis of angina: reduces the frequency of angina episodes when taken before exertion.
  • Heart failure (adjunct): assists in reducing preload and afterload as part of combination therapy.

How It Works

  • Glyceryl trinitrate is enzymatically converted to nitric oxide within vascular smooth‑muscle cells. The released nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle in veins and arteries. This vasodilation decreases venous return (preload) and arterial resistance (afterload), improving myocardial oxygen supply‑demand balance. The effect is rapid, peaking within minutes after sublingual administration, and is reversible as nitric oxide is metabolized.

Side Effects

Glyceryl trinitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: throbbing pain often triggered by vasodilation.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness.
  • Low blood pressure (orthostatic hypotension).

Serious or Rare Side Effects

  • Severe hypotension leading to fainting.
  • Syncope (sudden loss of consciousness).
  • Allergic reactions including rash or anaphylaxis.
  • Methemoglobinemia: abnormal hemoglobin causing cyanosis.

Precautions & Warnings

When prescribing Nitrocor, clinicians should consider several safety precautions to minimize risk.

  • Cardiovascular status: avoid in patients with severe hypotension or recent myocardial infarction.
  • Concomitant nitrates: do not combine with other nitrate preparations to prevent additive hypotension.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of profound hypotension.
  • Use in elderly: monitor blood pressure closely as sensitivity may be increased.
  • Pregnancy and lactation: use only if potential benefit justifies risk; data limited.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Nitrocor can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other nitrates or nitric oxide donors: additive vasodilatory effect causing severe hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound hypotension.
  • Guanylate cyclase stimulators: may amplify vasodilation.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (beta‑blockers, ACE inhibitors): may enhance blood pressure lowering.
  • Diuretics: can increase risk of orthostatic hypotension.
  • Alcohol: may potentiate vasodilatory effects.

Frequently Asked Questions

Nitrocor contains glyceryl trinitrate and is indicated for the acute relief of angina pectoris, prophylaxis of angina attacks, and as an adjunct in the management of heart failure. It works by rapidly dilating blood vessels to improve blood flow to the heart muscle.

Glyceryl trinitrate is converted to nitric oxide in vascular smooth‑muscle cells. Nitric oxide activates soluble guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle in veins and arteries. This reduces both preload and afterload, easing the heart's workload and relieving myocardial ischemia.

The dose of Nitrocor is individualized by the prescribing clinician based on the patient’s condition, severity of symptoms, and response to therapy. Healthcare professionals determine the appropriate sublingual tablet strength and frequency according to established clinical guidelines.

Safety data for Nitrocor in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To request Nitrocor, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrocor (glyceryl trinitrate) is a short‑acting nitrate, providing rapid onset of action within minutes, which distinguishes it from longer‑acting agents such as isosorbide dinitrate. While both classes relieve angina by vasodilation, Nitrocor is preferred for immediate symptom relief and for use before anticipated exertion.

Nitrocor tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct light, and ensure the container is tightly closed to maintain tablet integrity throughout its shelf life.

Nitrocor is supplied as a sublingual tablet. The patient places the tablet under the tongue and allows it to dissolve completely without swallowing. This route provides rapid absorption into the bloodstream, delivering quick relief of angina symptoms.

The most serious adverse events include severe hypotension, syncope (fainting), allergic reactions such as anaphylaxis, and methemoglobinemia. Patients should be monitored for sudden drops in blood pressure, loss of consciousness, or signs of a severe allergic response and seek immediate medical attention if they occur.

Nitrocor is contraindicated in patients with severe hypotension, recent myocardial infarction, or those taking phosphodiesterase‑5 inhibitors (e.g., sildenafil) due to the risk of profound blood‑pressure reduction. Caution is also advised for individuals with known hypersensitivity to nitrates.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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