Product image of Nitroderm Tts (Glyceryl Trinitrate) supplied by GNH India

Nitroderm Tts

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitroderm Tts (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitroderm Tts, is an organic nitrate presented as a transdermal patch for transdermal use. It reduces myocardial oxygen demand by vasodilating coronary vessels and is indicated for the management of chronic stable angina and for the prophylaxis of angina attacks in adult patients.

GNH India supplies Nitroderm Tts as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution. The company ensures batch‑to‑batch consistency and supports regulatory compliance for its partners.

Manufacturer / TM Owner

Sandoz S.P.A.

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Indications & Clinical Uses

  • Nitroderm Tts, an organic nitrate, is used to manage conditions related to coronary artery ischemia.
  • Chronic stable angina: reduces frequency and severity of angina episodes by improving myocardial blood flow.
  • Prophylaxis of angina attacks: maintains coronary vasodilation to prevent sudden chest pain during exertion.
  • Exercise‑induced angina: enhances exercise tolerance by decreasing cardiac workload.

How It Works

  • Glyceryl trinitrate acts as a nitric‑oxide donor. After transdermal absorption, it is converted to nitric oxide, which activates guanylate cyclase in vascular smooth‑muscle cells, increasing cyclic GMP levels. Elevated cGMP leads to relaxation of smooth muscle, causing dilation of veins and arteries, reducing preload and afterload, and lowering myocardial oxygen consumption. The effect is dose‑dependent and reversible, providing rapid onset of anti‑anginal action.

Side Effects

The most frequently reported adverse reactions with Nitroderm Tts are related to its vasodilatory properties.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after patch application.
  • Flushing: warmth and redness of the skin, especially on the face and neck.
  • Skin irritation at the patch site: erythema, itching or rash where the patch adheres.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical intervention.
  • Syncope: sudden loss of consciousness related to blood pressure drop.
  • Methemoglobinemia: rare blood disorder causing reduced oxygen delivery.

Precautions & Warnings

  • When prescribing Nitroderm Tts, clinicians should consider several safety measures.
  • Cardiovascular status: avoid use in patients with severe hypotension or uncontrolled hypertension.
  • Concomitant PDE5 inhibitors: contraindicated due to risk of profound hypotension.
  • Use with other nitrates: may cause additive vasodilation and severe blood pressure fall.
  • Anemia or increased intracranial pressure: monitor closely as vasodilation may exacerbate symptoms.
  • Pregnancy and lactation: safety not established; prescribe only if benefits outweigh risks.
  • Store at room temperature: keep in original packaging, protect from light and moisture.

Avoid Interactions

Nitroderm Tts can interact with several drug classes; careful assessment is required.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil, vardenafil): can cause life‑threatening hypotension.
  • Other organic nitrates (e.g., isosorbide dinitrate, mononitrate): additive vasodilatory effect may lead to severe hypotension.
  • Riociguat: synergistic vasodilatory action may result in dangerous blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia, requiring blood pressure monitoring.
  • Calcium‑channel blockers: combined effect can enhance hypotensive response.
  • Alcohol: can increase vasodilatory effect and dizziness.

Frequently Asked Questions

Nitroderm Tts is a transdermal patch that delivers glyceryl trinitrate, an organic nitrate, to treat chronic stable angina and to prevent angina attacks in adults. It works by improving blood flow to the heart, thereby reducing chest pain episodes during rest or physical activity.

Glyceryl trinitrate is a nitric‑oxide donor. Once absorbed through the skin, it is converted to nitric oxide, which activates guanylate cyclase in vascular smooth‑muscle cells. This raises cyclic GMP levels, causing relaxation of veins and arteries, lowering cardiac preload and afterload, and decreasing the heart’s oxygen demand.

The prescribed dose of Nitroderm Tts is determined by the treating physician based on the individual’s clinical condition. Typically, a single patch is applied once daily to a clean, dry skin area, and the dosing schedule should not be altered without medical advice.

Safety of Nitroderm Tts in pregnancy and lactation has not been established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under the guidance of a qualified healthcare professional.

To order Nitroderm Tts, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitroderm Tts provides continuous, controlled delivery of glyceryl trinitrate, unlike oral nitrates that require multiple daily doses and have variable absorption. Compared with beta‑blockers or calcium‑channel blockers, it directly dilates coronary vessels, offering rapid relief of ischemic pain but may cause more vasodilatory side effects such as headache.

Store the patch at room temperature, below 25 °C, in its original sealed pouch. Protect it from direct sunlight, moisture and heat. Keep the patch away from children and do not expose it to temperatures above the recommended range, as this may affect drug stability.

The patch is applied to a clean, dry, hair‑free area of the upper torso or upper arm. Press firmly for several seconds to ensure good adhesion, then replace the patch according to the prescriber’s schedule, usually every 24 hours. Rotate application sites to minimize skin irritation.

Serious risks include severe hypotension, which can lead to fainting or shock, syncope (sudden loss of consciousness), and rare cases of methemoglobinemia that impair oxygen delivery. Patients should be monitored for these events, especially when initiating therapy or adjusting concomitant medications.

Nitroderm Tts is contraindicated in patients with severe hypotension, known hypersensitivity to glyceryl trinitrate or any component of the patch, and in those taking phosphodiesterase‑5 inhibitors. Caution is also advised for individuals with anemia, increased intracranial pressure, or recent head trauma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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