Product image of Nitrofix (Glyceryl Trinitrate) supplied by GNH India

Nitrofix

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrofix (Glyceryl Trinitrate)

Glyceryl Trinitrate, the active ingredient in Nitrofix, is a nitrate vasodilator presented as a transdermal patch for transdermal use. It reduces myocardial oxygen demand by dilating veins and arteries, making it useful in the management of angina pectoris, acute coronary syndrome and as an adjunct in heart failure.

GNH India supplies Nitrofix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation to support import and distribution.

Manufacturer / TM Owner

Arafarma Group, S.A

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Indications & Clinical Uses

Nitrofix (glyceryl trinitrate) acts on the nitrate pathway to relieve myocardial ischemia.

  • Angina pectoris: reduces frequency and severity of chest pain by decreasing cardiac workload.
  • Acute coronary syndrome: improves coronary blood flow and limits ischemic injury during episodes.
  • Heart failure (adjunct therapy): lowers preload and myocardial oxygen consumption, supporting symptomatic management.

How It Works

  • Glyceryl trinitrate is a nitric oxide donor that is enzymatically converted to nitric oxide within vascular smooth‑muscle cells. The released nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle in veins and arteries. This vasodilation reduces venous return (preload) and arterial resistance (afterload), thereby decreasing myocardial oxygen demand and improving coronary perfusion.

Side Effects

Nitrofix may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: throbbing pain often triggered by vasodilation.
  • Flushing: warmth and redness of the skin.
  • Dizziness or light‑headedness: due to lowered blood pressure.
  • Hypotension: noticeable drop in blood pressure, especially upon standing.

Serious or Rare Side Effects

  • Methemoglobinemia: abnormal hemoglobin affecting oxygen transport.
  • Severe hypotension with syncope: sudden drop in blood pressure leading to fainting.

Precautions & Warnings

Before prescribing Nitrofix, clinicians should consider several safety measures and patient‑specific factors.

  • Cardiovascular assessment: evaluate for recent myocardial infarction or severe aortic stenosis.
  • Concomitant nitrate therapy: avoid combined use to prevent excessive hypotension.
  • Phosphodiesterase‑5 inhibitors: contraindicated due to risk of profound vasodilation.
  • Blood pressure monitoring: check baseline and orthostatic readings.
  • Store at room temperature: keep below 25°C in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nitrofix interacts with several drug classes that can modify its vasodilatory effect or increase toxicity.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause severe hypotension.
  • Other nitrates or nitrites: additive vasodilatory effect leading to dangerous blood pressure fall.
  • Guanylate cyclase stimulators: increase risk of hypotension.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (beta‑blockers, ACE inhibitors): may enhance blood pressure lowering.
  • Diuretics: can potentiate orthostatic hypotension.
  • Alcohol: may increase vasodilatory side effects.

Frequently Asked Questions

Nitrofix contains glyceryl trinitrate and is prescribed to manage angina pectoris, to treat acute coronary syndrome episodes, and as an adjunct therapy in heart failure to reduce cardiac workload and improve blood flow.

Glyceryl trinitrate releases nitric oxide in vascular smooth‑muscle cells, activating guanylate cyclase and raising cyclic GMP levels. This cascade relaxes veins and arteries, lowering preload and afterload, which decreases myocardial oxygen demand and relieves ischemic chest pain.

The dosage of Nitrofix is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, response, and tolerance. Specific dosing regimens are not provided here.

Safety data for Nitrofix in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Nitrofix, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrofix (glyceryl trinitrate) provides rapid onset vasodilation via nitric oxide donation, whereas agents like isosorbide dinitrate have a longer duration but may require oral dosing. Choice depends on clinical scenario, patient tolerance, and physician preference.

Store Nitrofix at room temperature, keeping it below 25 °C. Keep the patch in its original packaging, protect it from moisture and direct sunlight, and avoid exposing it to extreme temperatures that could affect drug stability.

Nitrofix is applied to clean, dry skin as a transdermal patch. The prescriber will specify the site of application, duration of wear, and any rotation schedule to ensure consistent drug delivery.

Serious risks include severe hypotension, syncope, and rare cases of methemoglobinemia. Patients should be monitored for sudden drops in blood pressure, fainting, or signs of impaired oxygen transport, and medical attention should be sought immediately if these occur.

Nitrofix should be avoided in patients with known hypersensitivity to glyceryl trinitrate or other nitrates, those taking phosphodiesterase‑5 inhibitors, and individuals with severe aortic stenosis or recent myocardial infarction unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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