Product image of Nitrofurantoin Dr. Reddy's Laboratories Uk (Nitrofurantoin) supplied by GNH India

Nitrofurantoin Dr. Reddy's Laboratories Uk

Active Ingredient:
Nitrofurantoin
Origin:
EU

Nitrofurantoin Dr. Reddy's Laboratories Uk (Nitrofurantoin)

Nitrofurantoin, the active ingredient in Nitrofurantoin Dr. Reddy's Laboratories Uk, is a nitrofuran antibiotic presented as an oral dosage form for oral use. It treats uncomplicated urinary tract infections, including cystitis, in adult patients. GNH India supplies Nitrofurantoin Dr. Reddy's Laboratories Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Reddy's Laboratories (Uk) Ltd

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Indications & Clinical Uses

Nitrofurantoin is a nitrofuran antibiotic used to manage infections of the urinary tract.

  • Uncomplicated urinary tract infection: eradicates susceptible bacteria causing lower urinary symptoms.
  • Cystitis: resolves bladder inflammation by eliminating the infecting organisms.
  • Prophylaxis of recurrent urinary infections: reduces the frequency of future episodes when prescribed for preventive therapy.

How It Works

  • Nitrofurantoin interferes with bacterial carbohydrate metabolism and cell‑wall synthesis by inhibiting bacterial enzyme systems. This disruption leads to accumulation of toxic metabolites and impairs DNA, RNA, and protein synthesis, producing bacteriostatic or bactericidal activity against common urinary pathogens such as Escherichia coli and Staphylococcus saprophyticus.

Side Effects

Adverse reactions may occur with nitrofurantoin therapy.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Loss of appetite: reduced desire to eat.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Diarrhea: loose stools.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Pulmonary toxicity: interstitial pneumonitis or fibrosis.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Hemolytic anemia: especially in patients with G6PD deficiency.
  • Severe hypersensitivity: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Acute kidney injury: sudden decline in renal function.

Precautions & Warnings

Before initiating nitrofurantoin, consider the following safety measures.

  • Renal function: avoid use if creatinine clearance is <60 mL/min.
  • Pregnancy: category B, use only if benefits outweigh risks.
  • Breastfeeding: monitor infant for gastrointestinal disturbances.
  • G6PD deficiency: contraindicated due to risk of hemolysis.
  • Elderly patients: start at lower dose and monitor for toxicity.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nitrofurantoin may interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce absorption of nitrofurantoin.
  • Probenecid: decreases renal excretion, increasing toxicity risk.
  • Fluoroquinolones: additive risk of tendon rupture.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Diuretics: may increase risk of crystalluria, ensure adequate hydration.
  • Oral contraceptives: possible reduction in efficacy, advise alternative contraception.

Frequently Asked Questions

Nitrofurantoin Dr. Reddy's Laboratories Uk is an oral nitrofuran antibiotic indicated for the treatment of uncomplicated urinary tract infections, including cystitis, caused by susceptible bacteria. It is prescribed to adult patients to clear infection and relieve urinary symptoms.

Nitrofurantoin disrupts bacterial carbohydrate metabolism and cell‑wall synthesis by inhibiting key enzyme systems. This leads to accumulation of toxic metabolites and impairs DNA, RNA, and protein synthesis, resulting in bacteriostatic or bactericidal activity against common urinary pathogens.

The dosage of Nitrofurantoin Dr. Reddy's Laboratories Uk is determined by the prescribing clinician based on the patient’s condition, renal function, and local guidelines. Patients should follow the prescriber’s instructions and the product label.

Nitrofurantoin is classified as pregnancy category B, indicating it may be used when the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk in small amounts; breastfeeding mothers should discuss risks and benefits with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with other agents such as trimethoprim‑sulfamethoxazole or fluoroquinolones, nitrofurantoin has a narrow spectrum focused on common urinary pathogens and a low propensity for promoting resistance. It is often preferred for uncomplicated infections but is unsuitable for patients with reduced renal function.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nitrofurantoin Dr. Reddy's Laboratories Uk is taken orally, usually with food or a full glass of water to improve absorption and reduce gastrointestinal irritation. The exact administration schedule should follow the prescriber’s directions.

Serious risks include pulmonary toxicity (interstitial pneumonitis or fibrosis), hepatotoxicity, hemolytic anemia in patients with G6PD deficiency, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and acute kidney injury. Patients should seek immediate medical attention if they experience respiratory difficulty, jaundice, severe rash, or sudden loss of kidney function.

Nitrofurantoin is contraindicated in patients with severe renal impairment (creatinine clearance <60 mL/min), known hypersensitivity to nitrofurantoin or other nitrofurans, and individuals with G6PD deficiency due to the risk of hemolysis. Caution is also advised for pregnant women near term and for patients with a history of pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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