Nitrofurantoin Kora Healthcare

Active Ingredient:: Nitrofurantoin
Origin:: EU

Nitrofurantoin Kora Healthcare (Nitrofurantoin)

Q: What is Nitrofurantoin Kora Healthcare used for?

Nitrofurantoin Kora Healthcare is indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria. It is commonly prescribed for acute cystitis and urethritis in adult patients, helping to clear the infection and relieve associated symptoms.

Q: How does Nitrofurantoin work?

The drug penetrates bacterial cells and inhibits enzymes that are essential for carbohydrate metabolism, particularly those in the electron transport chain. This interference disrupts nucleic acid and protein synthesis, leading to bacterial cell death, especially against common uropathogens.

Q: What is the usual dose of Nitrofurantoin Kora Healthcare?

The dosage of Nitrofurantoin Kora Healthcare is determined by the prescribing clinician based on the patient’s age, renal function, severity of infection and local treatment guidelines. The prescriber will select the appropriate strength, frequency and duration for each individual case.

Q: Is Nitrofurantoin safe during pregnancy or breastfeeding?

Nitrofurantoin is classified as pregnancy category B, indicating that animal studies have not shown risk and there are no well‑controlled human studies. It may be used when clearly needed, but clinicians should weigh benefits against potential risks, especially in the first trimester. Limited data suggest it is compatible with breastfeeding.

Q: How do I order Nitrofurantoin Kora Healthcare from GNH India?

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details and any necessary import documentation.

Q: How does Nitrofurantoin compare with the main alternative drug or class?

The most common alternative for uncomplicated urinary tract infections is trimethoprim‑sulfamethoxazole. Nitrofurantoin has a narrower spectrum focused on urinary pathogens and achieves high urinary concentrations, which can reduce systemic side effects. However, it is contraindicated in severe renal impairment, whereas trimethoprim‑sulfamethoxazole may be used in a broader range of renal function.

Q: How should Nitrofurantoin Kora Healthcare be stored and handled?

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight. Do not store in a bathroom or near a kitchen sink where humidity is high. Ensure the container is tightly closed after each use.

Q: How is Nitrofurantoin administered?

Nitrofurantoin is taken orally, usually with food or a full glass of water to improve absorption and reduce gastrointestinal irritation. The tablet or capsule should be swallowed whole; crushing or chewing is not recommended unless the prescriber specifically advises otherwise.

Q: What are the most serious risks to watch for while taking Nitrofurantoin?

Serious adverse reactions include pulmonary toxicity such as interstitial pneumonitis or fibrosis, hepatotoxicity presenting as elevated liver enzymes or hepatitis, and hemolytic anemia, particularly in patients with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical attention is required if any of these symptoms develop.

Q: Who should not use Nitrofurantoin?

Nitrofurantoin should be avoided in patients with severe renal impairment (eGFR < 30 mL/min), known hypersensitivity to nitrofurantoin or other nitrofurans, and individuals with glucose‑6‑phosphate dehydrogenase deficiency due to the risk of hemolysis. It is also contraindicated in patients who have experienced previous pulmonary toxicity from the drug.

Nitrofurantoin, the active ingredient in Nitrofurantoin Kora Healthcare, is a nitrofuran antibiotic presented as an oral formulation for systemic use. It is employed to treat uncomplicated urinary tract infections caused by susceptible bacteria in adult patients and is commonly prescribed in outpatient settings.

GNH India supplies Nitrofurantoin Kora Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with a focus on quality assurance and regulatory compliance. Our distribution network ensures timely delivery across multiple continents, adhering to local import requirements.

Manufacturer / TM Owner

Kora Corporation Limited

Select Quantity

Pack/s

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

First Name

Last Name

Phone

Delivery Country

Delivery PostCode/Zipcode

Select Your Profile

I have read and agree to the terms & conditions, including the privacy policy, return policy, and usage terms as applicable to this request.

Indications & Clinical Uses

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

Uncomplicated urinary tract infection: eradicates susceptible bacteria causing cystitis and urethritis.
Prophylaxis of recurrent urinary tract infection: reduces recurrence in patients with a history of multiple episodes.

How It Works

Nitrofurantoin exerts its antibacterial effect by entering bacterial cells and inhibiting enzymes involved in carbohydrate metabolism, particularly the bacterial electron transport chain. This disruption impairs the synthesis of nucleic acids and proteins, leading to bacterial cell death, especially in Gram‑negative uropathogens. The drug is concentrated in urine, achieving high local concentrations that exceed the minimum inhibitory concentrations for common uropathogens such as Escherichia coli, Enterococcus faecalis and Staphylococcus saprophyticus.

Side Effects

Nitrofurantoin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

Nausea: mild stomach upset that may improve when the medication is taken with food.
Diarrhea: loose, watery stools that can occur during the course of therapy.
Headache: transient headache without accompanying neurological deficits.
Skin rash: mild erythematous rash that usually resolves after discontinuation.

Serious or Rare Side Effects

Pulmonary toxicity: interstitial pneumonitis or chronic fibrosis that may develop after prolonged use and requires immediate drug cessation.
Hepatotoxicity: elevation of liver enzymes or hepatitis presenting with jaundice, fatigue and abdominal discomfort.
Hemolytic anemia: rapid destruction of red blood cells, particularly in individuals with glucose‑6‑phosphate dehydrogenase deficiency.

Precautions & Warnings

Before prescribing nitrofurantoin, clinicians should consider several precautionary measures to ensure safe use.

Renal function: assess creatinine clearance and avoid use in patients with severe renal impairment (eGFR <30 mL/min).
Pregnancy: use only when clearly needed; category B indicates no proven risk in human studies but caution is advised.
G6PD deficiency: screen patients as nitrofurantoin can precipitate hemolysis in deficient individuals.
Concomitant drugs: monitor for interactions that may increase nitrofurantoin levels or toxicity.
Allergic reactions: discontinue if hypersensitivity such as rash, pruritus or anaphylaxis occurs.
Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and light.

Avoid Interactions

Nitrofurantoin may interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption; separate dosing by at least 2 hours.
Probenecid: decreases renal excretion, increasing plasma concentrations and risk of toxicity.
Fluoroquinolones: concurrent use may increase risk of central nervous system adverse effects.
Cimetidine: may increase nitrofurantoin plasma levels, raising risk of toxicity.

Moderate Interactions (Monitor Closely)

Warfarin: nitrofurantoin can potentiate anticoagulant effect; monitor INR closely.
Oral contraceptives: may reduce efficacy of nitrofurantoin; assess need for alternative contraception.
Diuretics: may affect renal clearance of nitrofurantoin; monitor renal function.
Methenamine: combined use may increase risk of crystalluria; monitor urinary output.

Frequently Asked Questions

Nitrofurantoin Kora Healthcare is indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria. It is commonly prescribed for acute cystitis and urethritis in adult patients, helping to clear the infection and relieve associated symptoms.

The drug penetrates bacterial cells and inhibits enzymes that are essential for carbohydrate metabolism, particularly those in the electron transport chain. This interference disrupts nucleic acid and protein synthesis, leading to bacterial cell death, especially against common uropathogens.

The dosage of Nitrofurantoin Kora Healthcare is determined by the prescribing clinician based on the patient’s age, renal function, severity of infection and local treatment guidelines. The prescriber will select the appropriate strength, frequency and duration for each individual case.

Nitrofurantoin is classified as pregnancy category B, indicating that animal studies have not shown risk and there are no well‑controlled human studies. It may be used when clearly needed, but clinicians should weigh benefits against potential risks, especially in the first trimester. Limited data suggest it is compatible with breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details and any necessary import documentation.

The most common alternative for uncomplicated urinary tract infections is trimethoprim‑sulfamethoxazole. Nitrofurantoin has a narrower spectrum focused on urinary pathogens and achieves high urinary concentrations, which can reduce systemic side effects. However, it is contraindicated in severe renal impairment, whereas trimethoprim‑sulfamethoxazole may be used in a broader range of renal function.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight. Do not store in a bathroom or near a kitchen sink where humidity is high. Ensure the container is tightly closed after each use.

Nitrofurantoin is taken orally, usually with food or a full glass of water to improve absorption and reduce gastrointestinal irritation. The tablet or capsule should be swallowed whole; crushing or chewing is not recommended unless the prescriber specifically advises otherwise.

Serious adverse reactions include pulmonary toxicity such as interstitial pneumonitis or fibrosis, hepatotoxicity presenting as elevated liver enzymes or hepatitis, and hemolytic anemia, particularly in patients with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical attention is required if any of these symptoms develop.

Nitrofurantoin should be avoided in patients with severe renal impairment (eGFR < 30 mL/min), known hypersensitivity to nitrofurantoin or other nitrofurans, and individuals with glucose‑6‑phosphate dehydrogenase deficiency due to the risk of hemolysis. It is also contraindicated in patients who have experienced previous pulmonary toxicity from the drug.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 27 Sep 2026

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.