Nitrofurantoin Olikla

Active Ingredient:: Nitrofurantoin, Macrocrystalline
Origin:: EU

Nitrofurantoin Olikla (Nitrofurantoin, Macrocrystalline)

Q: What is Nitrofurantoin Olikla used for?

Nitrofurantoin Olikla is indicated for the treatment of uncomplicated urinary tract infections, particularly acute cystitis, in adult patients. It may also be prescribed for prophylaxis of recurrent urinary tract infections when deemed appropriate by the prescriber.

Q: How does nitrofurantoin work?

Nitrofurantoin is converted by bacterial nitroreductases into reactive metabolites that bind to bacterial DNA, proteins, and other macromolecules. This interaction disrupts essential cellular functions, resulting in bactericidal activity that is concentrated in the urinary tract where the drug is excreted.

Q: What is the usual dose of Nitrofurantoin Olikla?

The dosage of Nitrofurantoin Olikla is determined by the prescribing clinician based on the patient’s condition, renal function, and other clinical factors. Patients should follow the exact regimen provided on the prescription label.

Q: Is Nitrofurantoin Olikla safe during pregnancy or breastfeeding?

The safety of Nitrofurantoin Olikla in pregnancy is not fully established, and it is generally avoided unless the benefits outweigh potential risks. Limited data are available for breastfeeding; clinicians should assess the risk‑benefit ratio before prescribing.

Q: How do I order Nitrofurantoin Olikla from GNH India?

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Q: How does Nitrofurantoin compare with other urinary anti‑infectives?

Nitrofurantoin offers high urinary concentrations with limited systemic exposure, making it effective for lower urinary tract infections. Compared with trimethoprim‑sulfamethoxazole or fluoroquinolones, it has a narrower spectrum but a lower risk of promoting broad‑spectrum resistance.

Q: What are the storage and handling requirements for Nitrofurantoin Olikla?

Store Nitrofurantoin Olikla tablets at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Q: How is Nitrofurantoin Olikla administered?

Nitrofurantoin Olikla is taken orally with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal upset. Patients should swallow the tablet whole and not crush or chew it.

Q: What are the most serious risks associated with Nitrofurantoin Olikla?

Serious adverse events include pulmonary toxicity (interstitial pneumonitis or fibrosis), hepatic injury, and hemolytic anemia, especially in individuals with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical evaluation is required if any of these symptoms develop.

Q: Who should not use Nitrofurantoin Olikla?

Nitrofurantoin Olikla should be avoided in patients with severe renal impairment (creatinine clearance <30 mL/min), known hypersensitivity to nitrofurantoin, or G6PD deficiency due to the risk of hemolysis. Caution is also advised in pregnant women and the elderly.

Nitrofurantoin, the active ingredient in Nitrofurantoin Olikla, is a nitrofuran antibiotic presented as a tablet for oral use. It exerts bactericidal activity in the urinary tract and is indicated for the treatment of uncomplicated urinary tract infections, such as acute cystitis, in adult patients.

GNH India supplies Nitrofurantoin Olikla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution through reliable logistics networks.

Manufacturer / TM Owner

Olikla S.R.O.

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Indications & Clinical Uses

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

Uncomplicated urinary tract infection (cystitis): eradicates the causative bacteria and resolves urinary symptoms.
Acute uncomplicated lower urinary tract infection: provides rapid bactericidal activity in the bladder.
Prevention of recurrent urinary tract infections: used as a prophylactic agent to reduce the frequency of future episodes.

How It Works

Nitrofurantoin is reduced by bacterial nitroreductases within the urinary tract to reactive intermediates that covalently bind bacterial DNA, proteins, and other macromolecules. This damage disrupts essential cellular processes, leading to bactericidal activity that is concentrated in the urine where the drug achieves therapeutic concentrations.

Side Effects

Nitrofurantoin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

Nausea: mild to moderate upset stomach.
Loss of appetite: reduced desire to eat.
Headache: transient cranial discomfort.
Urine discoloration: brownish or dark urine without clinical significance.

Serious or Rare Side Effects

Pulmonary toxicity: interstitial pneumonitis or fibrosis requiring immediate medical attention.
Hepatic injury: hepatitis or liver enzyme elevation.
Hemolytic anemia: especially in patients with G6PD deficiency.

Precautions & Warnings

Before prescribing Nitrofurantoin, clinicians should consider several safety aspects.

Renal function: avoid use in patients with severely reduced creatinine clearance (<30 mL/min).
G6PD deficiency: contraindicated due to risk of hemolysis.
Pregnancy: use only if clearly needed; safety category is unknown.
Elderly patients: monitor for pulmonary and hepatic adverse effects.
Drug hypersensitivity: discontinue if rash or allergic reaction occurs.
Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Nitrofurantoin can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

Antacids containing magnesium or aluminum: reduce absorption of nitrofurantoin.
Probenecid: decreases renal excretion, increasing systemic exposure.
Fluoroquinolones: additive risk of tendon toxicity.

Moderate Interactions (Monitor Closely)

Warfarin: may enhance anticoagulant effect; monitor INR.
Diuretics: may affect renal clearance and increase toxicity risk.
Oral contraceptives: potential reduction in contraceptive efficacy.

Frequently Asked Questions

Nitrofurantoin Olikla is indicated for the treatment of uncomplicated urinary tract infections, particularly acute cystitis, in adult patients. It may also be prescribed for prophylaxis of recurrent urinary tract infections when deemed appropriate by the prescriber.

Nitrofurantoin is converted by bacterial nitroreductases into reactive metabolites that bind to bacterial DNA, proteins, and other macromolecules. This interaction disrupts essential cellular functions, resulting in bactericidal activity that is concentrated in the urinary tract where the drug is excreted.

The dosage of Nitrofurantoin Olikla is determined by the prescribing clinician based on the patient’s condition, renal function, and other clinical factors. Patients should follow the exact regimen provided on the prescription label.

The safety of Nitrofurantoin Olikla in pregnancy is not fully established, and it is generally avoided unless the benefits outweigh potential risks. Limited data are available for breastfeeding; clinicians should assess the risk‑benefit ratio before prescribing.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nitrofurantoin offers high urinary concentrations with limited systemic exposure, making it effective for lower urinary tract infections. Compared with trimethoprim‑sulfamethoxazole or fluoroquinolones, it has a narrower spectrum but a lower risk of promoting broad‑spectrum resistance.

Store Nitrofurantoin Olikla tablets at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Nitrofurantoin Olikla is taken orally with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal upset. Patients should swallow the tablet whole and not crush or chew it.

Serious adverse events include pulmonary toxicity (interstitial pneumonitis or fibrosis), hepatic injury, and hemolytic anemia, especially in individuals with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical evaluation is required if any of these symptoms develop.

Nitrofurantoin Olikla should be avoided in patients with severe renal impairment (creatinine clearance <30 mL/min), known hypersensitivity to nitrofurantoin, or G6PD deficiency due to the risk of hemolysis. Caution is also advised in pregnant women and the elderly.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 27 Sep 2026

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