Product image of Nitrofurantoina Doc (Nitrofurantoin) supplied by GNH India

Nitrofurantoina Doc

Active Ingredient:
Nitrofurantoin
Origin:
EU

Nitrofurantoina Doc (Nitrofurantoin)

Nitrofurantoin, the active ingredient in Nitrofurantoina Doc, is a nitrofuran antibiotic presented as an oral formulation for oral use. It exerts bactericidal activity against common urinary pathogens such as Escherichia coli and Enterococcus species, and is indicated for the treatment of uncomplicated urinary tract infections, including cystitis, in adult patients.

GNH India supplies Nitrofurantoina Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across EU and global markets through robust quality‑assurance processes.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

  • Nitrofurantoina Doc is a nitrofuran antibiotic used to treat infections of the urinary tract.
  • Uncomplicated urinary tract infection: eliminates the causative bacteria and resolves symptoms.
  • Cystitis: clears bladder infection and prevents recurrence.
  • Recurrent urinary tract infection prophylaxis: provides short‑term preventive therapy to reduce recurrence risk.

How It Works

  • Nitrofurantoin interferes with bacterial carbohydrate metabolism by inhibiting bacterial enzyme systems such as pyruvate dehydrogenase and other flavoprotein‑dependent pathways. This disruption impairs synthesis of nucleic acids and cell wall components, leading to rapid bactericidal activity against susceptible urinary pathogens, particularly Gram‑negative rods and some Gram‑positive cocci. The drug concentrates in urine, achieving high local concentrations while systemic exposure remains low, which enhances its selectivity for urinary pathogens.

Side Effects

Nitrofurantoina Doc may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset occurring after dosing.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools that may be transient.
  • Headache: mild to moderate cranial pain.
  • Loss of appetite: reduced desire to eat.
  • Metallic taste: transient alteration of taste perception.

Serious or Rare Side Effects

  • Pulmonary toxicity: interstitial lung disease or acute respiratory distress.
  • Liver injury: hepatitis or elevated liver enzymes.
  • Severe allergic reactions: rash, Stevens‑Johnson syndrome, or anaphylaxis.
  • Hemolytic anemia in G6PD deficiency: rapid destruction of red blood cells.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Blood dyscrasias: agranulocytosis, leukopenia, or thrombocytopenia.

Precautions & Warnings

  • When prescribing Nitrofurantoina Doc, clinicians should consider several safety aspects to minimise risk.
  • Renal function: assess kidney function and avoid use if creatinine clearance is below 60 mL/min.
  • Pregnancy: avoid use unless benefits outweigh risks, especially during the first trimester.
  • G6PD deficiency: contraindicated due to risk of hemolysis.
  • History of lung disease: monitor for pulmonary reactions.
  • Concurrent antacids: separate dosing as antacids may reduce absorption.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nitrofurantoina Doc can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: decrease nitrofurantoin absorption.
  • Probenecid: reduces renal excretion, increasing systemic exposure.
  • Warfarin: may potentiate anticoagulant effect and raise INR.
  • Oral contraceptives: may reduce hormonal effectiveness.

Moderate Interactions (Monitor Closely)

  • Diuretics: may increase nitrofurantoin concentration, raising renal risk.
  • NSAIDs: combined use can stress renal function.
  • High‑dose vitamin C: may enhance absorption and side‑effect potential.

Frequently Asked Questions

Nitrofurantoina Doc contains nitrofurantoin, an antibiotic indicated for the treatment of uncomplicated urinary tract infections, including cystitis, and may be used for short‑term prophylaxis in patients with recurrent infections.

Nitrofurantoin disrupts bacterial carbohydrate metabolism by inhibiting key enzyme systems, leading to impaired nucleic‑acid and cell‑wall synthesis. This results in rapid bactericidal activity against common urinary pathogens, while the drug concentrates primarily in the urine.

The dosage of Nitrofurantoina Doc is individualized by the prescribing clinician based on the patient’s condition, renal function, and local guidelines. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy.

Nitrofurantoina Doc is generally avoided during pregnancy, especially in the first trimester, unless the potential benefit justifies the risk. Limited data exist for breastfeeding; clinicians should weigh the advantages against possible exposure to the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with agents such as trimethoprim‑sulfamethoxazole, nitrofurantoin offers a narrow spectrum focused on urinary pathogens and achieves high urinary concentrations with limited systemic exposure. It is often preferred for patients with resistant E. coli strains, though renal function and contraindications must be considered.

Store Nitrofurantoina Doc at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid crushing or splitting tablets unless instructed by a pharmacist.

Nitrofurantoina Doc is taken orally, usually with a full glass of water. It can be taken with or without food, but if antacids are used, they should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include pulmonary toxicity, severe liver injury, hemolytic anemia in patients with G6PD deficiency, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if symptoms like shortness of breath, jaundice, or severe rash develop.

Patients with significant renal impairment (creatinine clearance <60 mL/min), known G6PD deficiency, a history of nitrofurantoin‑induced lung disease, or hypersensitivity to nitrofurantoin or other nitrofurans should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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