Product image of Nitroglicerina Sandoz (Glyceryl Trinitrate) supplied by GNH India

Nitroglicerina Sandoz

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitroglicerina Sandoz (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitroglicerina Sandoz, is an organic nitrate presented as a cutaneous formulation for transdermal use. It is employed to relieve angina and other ischemic heart conditions in adult patients. It works by releasing nitric oxide, which relaxes vascular smooth muscle and reduces myocardial oxygen demand, providing rapid symptom relief.

GNH India supplies Nitroglicerina Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU market standards and is manufactured under strict quality controls.

Manufacturer / TM Owner

Sandoz S.P.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nitroglicerina Sandoz (glyceryl trinitrate) is used in the management of coronary artery disease and related ischemic conditions.

  • Angina pectoris: provides rapid relief of chest pain by dilating coronary arteries.
  • Acute coronary syndrome: reduces myocardial oxygen demand during unstable episodes.
  • Heart failure: improves symptoms by decreasing preload and afterload.

How It Works

  • Glyceryl trinitrate is enzymatically converted to nitric oxide within vascular smooth muscle cells. The nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle in veins and arteries. Venous dilation reduces preload, while arterial dilation lowers afterload, collectively decreasing myocardial oxygen consumption and alleviating ischemic pain. The effect is rapid, with onset within minutes after transdermal application, and it is reversible as nitric oxide is metabolized.

Side Effects

Glyceryl trinitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: throbbing pain often triggered by vasodilation.
  • Flushing: warm sensation and redness of the skin.
  • Dizziness: light‑headed feeling, especially when standing quickly.
  • Hypotension: drop in blood pressure causing faintness.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall leading to syncope.
  • Methemoglobinemia: elevated methemoglobin causing cyanosis.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Tachycardia: rapid heart rate associated with hypotension.

Precautions & Warnings

When prescribing or using Nitroglicerina Sandoz, several precautions should be observed to ensure safety.

  • Contraindication: avoid in patients with known hypersensitivity to organic nitrates.
  • Cardiovascular status: use cautiously in patients with severe aortic stenosis or recent myocardial infarction.
  • Concomitant medications: monitor for additive hypotensive effects when combined with antihypertensives.
  • Tolerance: limit continuous exposure to reduce risk of nitrate tolerance; drug‑free intervals may be required.
  • Pregnancy and lactation: assess risk‑benefit; limited data available, use only if clearly needed.
  • Store below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Glyceryl trinitrate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause profound hypotension.
  • Other nitrates or nitric oxide donors: risk of severe blood pressure fall.
  • Guanylate cyclase stimulators: additive vasodilatory effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors): may enhance hypotensive response.
  • Alcohol: can increase vasodilatory effect and dizziness.
  • Diuretics: may potentiate blood pressure reduction.

Frequently Asked Questions

Nitroglicerina Sandoz contains glyceryl trinitrate, an organic nitrate that is prescribed to relieve chest pain in angina pectoris, to manage acute coronary syndrome episodes, and to improve symptoms of heart failure by reducing cardiac workload.

Glyceryl trinitrate is converted inside vascular smooth‑muscle cells to nitric oxide. The nitric oxide stimulates soluble guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle in veins and arteries, lowering preload and afterload and decreasing myocardial oxygen demand.

The dosage of Nitroglicerina Sandoz is individualized. A qualified prescriber determines the appropriate strength, frequency, and duration based on the patient’s clinical condition, response, and tolerance. No generic dosing schedule is provided here.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nitroglicerina Sandoz belongs to the organic nitrate class, offering rapid vasodilation. Compared with beta‑blockers or calcium‑channel blockers, nitrates act directly on vascular smooth muscle and provide quick symptom relief, but they may cause tolerance with continuous use, requiring drug‑free intervals.

Store the product below 25 °C in its original packaging, protecting it from moisture, heat and direct light. Keep the container tightly closed and avoid crushing or exposing the cutaneous formulation to excessive humidity.

Nitroglicerina Sandoz is applied to the skin as a cutaneous formulation (e.g., patch or ointment). The prescriber will instruct the patient on the exact site, duration of application and any required drug‑free periods to minimise tolerance.

Serious risks include severe hypotension that can lead to syncope, methemoglobinemia causing reduced oxygen delivery, and allergic reactions ranging from rash to anaphylaxis. Patients should seek immediate medical attention if they experience fainting, cyanosis, or signs of a severe allergic response.

Individuals with known hypersensitivity to glyceryl trinitrate or other organic nitrates should avoid the product. It is also contraindicated in patients with severe aortic stenosis, uncontrolled hypotension, or those taking phosphodiesterase‑5 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Glyceryl Trinitrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT