Product image of Nitroglycerin Macure (Glyceryl Trinitrate) supplied by GNH India

Nitroglycerin Macure

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitroglycerin Macure (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitroglycerin Macure, is an organic nitrate presented as an intravenous solution for intravenous use. It is employed to relieve myocardial ischemia in acute angina pectoris, heart failure and myocardial infarction in adult patients.

GNH India supplies Nitroglycerin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Macure Healthcare Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nitroglycerin Macure belongs to the organic nitrate class and is used to manage conditions caused by myocardial oxygen demand‑supply mismatch.

  • Acute angina pectoris: provides rapid relief of chest pain by reducing preload and afterload.
  • Heart failure: improves cardiac output by decreasing ventricular filling pressures.
  • Myocardial infarction: limits infarct expansion by enhancing coronary blood flow and reducing myocardial workload.

How It Works

  • Glyceryl trinitrate is enzymatically converted to nitric oxide within vascular smooth muscle. The released nitric oxide activates guanylate cyclase, increasing cyclic GMP levels, which relaxes smooth muscle, produces vasodilation, lowers systemic and pulmonary vascular resistance, and reduces cardiac preload and afterload, thereby alleviating myocardial ischemia.

Side Effects

Nitroglycerin Macure may cause a range of adverse reactions. Monitoring and prompt management are recommended.

Common Side Effects

  • Headache: throbbing pain often related to cerebral vasodilation.
  • Hypotension: drop in blood pressure, especially with rapid infusion.
  • Flushing: warm, reddened skin sensation.
  • Tachycardia: compensatory increase in heart rate.
  • Dizziness: sensation of light‑headedness.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Methemoglobinemia: reduced oxygen‑carrying capacity of blood.
  • Severe hypotension: may lead to syncope or organ hypoperfusion.
  • Paradoxical myocardial ischemia: chest pain despite therapy.
  • Allergic reaction: rash, pruritus, or anaphylaxis.
  • Life‑threatening arrhythmia: ventricular tachycardia or fibrillation.
  • Syncope: sudden loss of consciousness.

Precautions & Warnings

Use of Nitroglycerin Macure requires careful clinical assessment and monitoring.

  • Blood pressure monitoring: check systolic pressure before and during infusion.
  • Severe anemia: avoid or use with caution due to reduced oxygen delivery.
  • Intracranial pressure: contraindicated in patients with raised intracranial pressure.
  • Concomitant PDE5 inhibitors: avoid because of additive hypotensive effect.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Nitroglycerin Macure can interact with several drug classes, altering its safety profile.

Major Interactions (Avoid)

  • Other nitrates (e.g., isosorbide dinitrate): risk of profound hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): additive vasodilatory effect leading to severe hypotension.
  • Alcohol: may potentiate blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt tachycardic response to hypotension.
  • Calcium channel blockers: additive vasodilatory effect.
  • Diuretics: may enhance volume depletion and hypotension.
  • ACE inhibitors or ARBs: combined effect on blood pressure.
  • Antihypertensives: overall blood pressure control requires adjustment.

Frequently Asked Questions

Nitroglycerin Macure is an intravenous formulation of glyceryl trinitrate used to treat acute angina pectoris, manage heart failure, and limit damage during myocardial infarction by rapidly relieving myocardial ischemia.

Glyceryl trinitrate is converted to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing relaxation of the muscle, vasodilation, reduced preload and afterload, and improved coronary blood flow, thereby easing cardiac workload.

The specific dose and infusion rate of Nitroglycerin Macure are determined by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Dosage is individualized and not standardized in public information.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitroglycerin Macure, as an organic nitrate, provides rapid vasodilation and is especially useful for acute symptom relief, whereas other classes such as beta‑blockers or calcium channel blockers act more slowly and primarily reduce heart rate or contractility. Choice depends on clinical urgency and patient tolerance.

The product should be stored at room temperature, below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability and potency.

Nitroglycerin Macure is given intravenously, typically as a continuous infusion or intermittent bolus under close hemodynamic monitoring. Administration is performed by qualified healthcare personnel in a setting equipped for cardiovascular monitoring.

The most serious risks include severe hypotension, methemoglobinemia, paradoxical myocardial ischemia, life‑threatening arrhythmias, and anaphylactic reactions. Prompt recognition and management of these events are essential during therapy.

Patients with known hypersensitivity to glyceryl trinitrate or other organic nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24 hours, and individuals with severe anemia, increased intracranial pressure, or uncontrolled hypotension should not receive this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Glyceryl Trinitrate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT