Product image of Nitroglycerine Macure (Glyceryl Trinitrate) supplied by GNH India

Nitroglycerine Macure

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitroglycerine Macure (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitroglycerine Macure, is a nitrate vasodilator presented as an intravenous solution for intravenous administration. It rapidly relieves coronary artery spasm, reduces myocardial oxygen demand, and is employed in the acute management of angina pectoris, myocardial ischemia, acute heart failure, and hypertensive emergencies in hospital patients.

GNH India supplies Nitroglycerine Macure as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macure Healthcare Limited

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Indications & Clinical Uses

Nitroglycerine Macure (glyceryl trinitrate) is used in the nitrate vasodilator class to manage acute coronary and cardiac conditions.

  • Acute angina pectoris: rapid relief of chest pain by dilating coronary arteries.
  • Myocardial ischemia: improves oxygen delivery by reducing cardiac workload.
  • Acute heart failure: lowers preload and afterload to ease ventricular strain.
  • Hypertensive emergencies: produces prompt blood pressure reduction through systemic vasodilation.

How It Works

  • Glyceryl trinitrate is enzymatically converted to nitric oxide within vascular smooth‑muscle cells. The released nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle and vasodilation of both veins and arteries, decreasing preload and afterload and lowering myocardial oxygen consumption.

Side Effects

Adverse reactions may occur with intravenous glyceryl trinitrate and are categorized by frequency.

Common Side Effects

  • Headache: throbbing pain due to cerebral vasodilation.
  • Flushing: warmth and redness of the skin.
  • Hypotension: drop in blood pressure causing dizziness.
  • Tachycardia: compensatory increase in heart rate.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: feeling of light‑headedness.

Serious or Rare Side Effects

  • Severe hypotension: can lead to syncope or shock.
  • Myocardial infarction: rare but possible in vulnerable patients.
  • Methemoglobinemia: abnormal hemoglobin reducing oxygen transport.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Life‑threatening arrhythmias: irregular heart rhythms requiring urgent care.

Precautions & Warnings

Careful monitoring and specific actions are required when using intravenous glyceryl trinitrate.

  • Monitor blood pressure: observe for excessive hypotension after each dose.
  • Assess heart rate: watch for reflex tachycardia or bradycardia.
  • Evaluate cardiac status: avoid in patients with recent myocardial infarction unless directed.
  • Use caution with concurrent vasodilators: risk of additive blood pressure lowering.
  • Pregnancy category B: consider risk‑benefit ratio before use in pregnant women.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Glyceryl trinitrate can interact with several drug classes, requiring avoidance or close monitoring.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause profound hypotension.
  • Other nitrates or nitrites: additive vasodilatory effect leading to severe hypotension.
  • Guanylate cyclase stimulators: excessive vasodilation risk.
  • Severe anemia: heightened sensitivity to blood pressure changes.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors): may require dose adjustment.
  • Diuretics: can amplify volume‑depletion effects.
  • Alcohol: potentiates hypotensive response.

Frequently Asked Questions

Nitroglycerine Macure contains glyceryl trinitrate and is used intravenously to provide rapid relief of acute angina pectoris, manage myocardial ischemia, treat acute heart failure, and control hypertensive emergencies in hospital settings.

Glyceryl trinitrate is converted to nitric oxide in vascular smooth‑muscle cells. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle, dilates veins and arteries, and reduces cardiac preload, afterload, and oxygen demand.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Dosing is individualized and should follow the prescriber’s instructions.

Glyceryl trinitrate is classified as pregnancy category B, indicating no evidence of risk in animal studies but limited human data. It should be used only if the potential benefit justifies the potential risk to the fetus, and caution is advised during breastfeeding.

Enquiries are submitted via the product page at gnhindia.com where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Compared with oral nitrates or beta‑blockers, intravenous glyceryl trinitrate offers a rapid onset of action suitable for emergency situations. It provides immediate vasodilation, whereas oral agents have slower absorption and are used for chronic management.

Store the product at room temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from light, moisture, and extreme temperatures. Do not freeze or shake the solution before use.

The medication is supplied as an intravenous solution and is administered by slow infusion through a calibrated IV set under continuous hemodynamic monitoring. Administration techniques follow hospital protocols for IV drug delivery.

Serious risks include severe hypotension, myocardial infarction, life‑threatening arrhythmias, and methemoglobinemia. Immediate medical attention is required if any of these events occur during or after infusion.

Patients with known hypersensitivity to nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24 hours, or individuals with severe anemia or uncontrolled hypotension should not receive this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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