Product image of Nitrolingual Akut (Glyceryl Trinitrate) supplied by GNH India

Nitrolingual Akut

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrolingual Akut (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitrolingual Akut, is a nitrate vasodilator presented as an oromucosal spray for rapid oromucosal administration. It acts to quickly relieve episodes of acute angina pectoris by dilating coronary and peripheral vessels, thereby reducing myocardial oxygen demand in adult patients.

GNH India supplies Nitrolingual Akut as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing consistent quality and regulatory‑aligned sourcing for global healthcare providers. The company adheres to EU GMP standards and offers reliable logistics for timely delivery.

Manufacturer / TM Owner

G. Pohl-Boskamp Gmbh Co. Kg

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Indications & Clinical Uses

  • Nitrolingual Akut, a nitrate vasodilator, is used in the management of coronary artery disease presenting with angina.
  • Acute angina pectoris: provides rapid relief of chest pain by dilating coronary vessels.
  • Stable angina: offers symptomatic relief of chest discomfort during exertion.
  • Angina prophylaxis: can be taken prior to physical activity to reduce the likelihood of an attack.

How It Works

  • Glyceryl trinitrate acts as a nitric oxide donor; it is enzymatically converted to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of coronary and peripheral vessels, lowering myocardial oxygen demand and improving blood flow during episodes of ischemia.

Side Effects

The most frequently reported reactions to Glyceryl trinitrate oromucosal spray are listed below.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after administration.
  • Flushing: warmth and redness of the face or neck.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Hypotension: transient drop in blood pressure causing faintness.
  • Tachycardia: compensatory increase in heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall leading to syncope.
  • Methemoglobinemia: rare blood disorder causing cyanosis.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Nitrolingual Akut, consider the following precautions to ensure safe use.

  • Contraindication: avoid in patients with known hypersensitivity to nitrates.
  • Blood pressure monitoring: check for excessive hypotension before and after use.
  • Drug combination: do not co‑administer with other nitrate preparations.
  • Phosphodiesterase‑5 inhibitors: avoid concurrent use due to risk of severe hypotension.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Glyceryl trinitrate may interact with several medicines; awareness of these interactions helps prevent adverse events.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, vardenafil: concurrent use can cause profound hypotension.
  • Other nitrates (e.g., isosorbide dinitrate): additive vasodilatory effect leading to severe blood pressure drop.
  • Sodium nitroprusside: combined effect may result in excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia that signals low blood pressure.
  • Diuretics: can enhance hypotensive response.
  • Antihypertensive agents (ACE inhibitors, ARBs, calcium channel blockers): additive blood pressure lowering effect.

Frequently Asked Questions

Nitrolingual Akut is an oromucosal spray containing glyceryl trinitrate that is prescribed to relieve episodes of acute angina pectoris. It works by rapidly dilating coronary vessels, which helps reduce chest pain caused by reduced blood flow to the heart muscle.

Glyceryl trinitrate is converted to nitric oxide after administration. Nitric oxide activates guanylate cyclase, increasing cyclic GMP levels in vascular smooth muscle. This cascade causes relaxation of coronary and peripheral arteries, lowering myocardial oxygen demand and improving blood flow during an angina attack.

The dosage of Nitrolingual Akut is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and response to therapy. Healthcare professionals adjust the number of sprays and frequency according to individual needs and clinical guidelines.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Nitrolingual Akut, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nitrolingual Akut delivers glyceryl trinitrate via an oromucosal spray, offering rapid onset of action compared with oral tablets. Unlike longer‑acting nitrate preparations, the spray is intended for immediate relief of acute attacks and can be used without the need for sublingual tablets, providing a convenient alternative for quick symptom control.

Nitrolingual Akut should be stored at room temperature, below 25 °C, in its original packaging. Keep the spray away from moisture, direct sunlight, and extreme temperatures to maintain potency and ensure the device functions correctly.

The product is an oromucosal spray. The patient places the nozzle inside the mouth, typically under the tongue or against the inner cheek, and actuates the device to deliver a measured dose. The spray is absorbed through the oral mucosa, providing rapid systemic exposure.

The most serious risks include severe hypotension, which can lead to fainting or shock, and rare cases of methemoglobinemia or allergic reactions such as anaphylaxis. Patients should be monitored for signs of excessive blood‑pressure drop and seek immediate medical attention if serious symptoms develop.

Nitrolingual Akut is contraindicated in individuals with known hypersensitivity to glyceryl trinitrate or any nitrate, and in patients who have taken phosphodiesterase‑5 inhibitors within the past 24‑48 hours due to the risk of dangerous blood‑pressure reductions. Clinicians should also exercise caution in patients with severe anemia or recent head injury.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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