Product image of Nitrolingual Pumpspray (Glyceryl Trinitrate) supplied by GNH India

Nitrolingual Pumpspray

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrolingual Pumpspray (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitrolingual Pumpspray, is a nitrate vasodilator presented as an oral spray (pump spray) for oromucosal use. It treats acute angina pectoris and is used for prophylaxis of angina attacks in adult patients. It provides rapid relief of chest pain by dilating coronary vessels and reducing myocardial oxygen demand.

GNH India supplies Nitrolingual Pumpspray as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed under a prescription‑only status.

Manufacturer / TM Owner

G. Pohl-Boskamp Gmbh Co. Kg

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Indications & Clinical Uses

Nitrolingual Pumpspray (glyceryl trinitrate) is used in the management of coronary artery disease‑related chest pain.

  • Acute angina pectoris: rapid relief of chest pain by vasodilation of coronary arteries.
  • Prophylaxis of angina attacks: decreases the frequency and severity of angina episodes.
  • Exercise‑induced angina: helps prevent chest discomfort during physical activity.

How It Works

  • Glyceryl trinitrate is enzymatically converted to nitric oxide in vascular smooth muscle. The released nitric oxide activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of venous and arterial smooth muscle, reducing preload and afterload and consequently lowering myocardial oxygen demand.

Side Effects

Nitrolingual Pumpspray may cause several adverse reactions.

Common Side Effects

  • Headache: throbbing sensation often occurring shortly after administration.
  • Flushing: warmth and redness of the face and neck.
  • Dizziness: light‑headed feeling, especially when standing quickly.
  • Hypotension: drop in blood pressure causing faintness.
  • Nausea: feeling of stomach upset.
  • Palpitations: awareness of rapid or irregular heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Syncope: sudden loss of consciousness.
  • Methemoglobinemia: rare blood disorder causing reduced oxygen delivery.
  • Allergic reaction: rash, itching, swelling, or angioedema.
  • Reflex tachycardia: compensatory rapid heart rate that may be problematic in certain cardiac conditions.

Precautions & Warnings

Before using Nitrolingual Pumpspray, consider the following safety measures.

  • Severe hypotension: avoid use in patients with markedly low blood pressure and monitor closely.
  • Concomitant nitrates: do not combine with other nitrate preparations to prevent additive vasodilation.
  • Phosphodiesterase‑5 inhibitors: avoid co‑administration due to risk of profound hypotension.
  • Anemia or increased intracranial pressure: use with caution as symptoms may worsen.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Nitrolingual Pumpspray can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Sildenafil, tadalafil, vardenafil (PDE‑5 inhibitors): may cause severe hypotension.
  • Other nitrates (e.g., isosorbide dinitrate, nitroglycerin): additive vasodilatory effect.
  • Alcohol: can enhance hypotensive response.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia, requiring blood pressure monitoring.
  • Calcium channel blockers: additive blood pressure lowering.
  • Diuretics: may increase risk of hypotension.
  • Antihypertensive agents: overall blood pressure effect should be observed.

Frequently Asked Questions

Nitrolingual Pumpspray contains glyceryl trinitrate and is prescribed to relieve acute angina pectoris and to prevent future angina attacks in patients with coronary artery disease. It works by rapidly dilating coronary vessels, providing prompt chest‑pain relief and reducing the workload of the heart.

Glyceryl trinitrate is a pro‑drug that releases nitric oxide after absorption through the oral mucosa. Nitric oxide activates guanylate cyclase, raising cyclic GMP levels, which relaxes smooth muscle in veins and arteries. This vasodilation lowers cardiac preload and afterload, decreasing myocardial oxygen demand and alleviating angina.

The specific dose and frequency of Nitrolingual Pumpspray are determined by the prescribing clinician based on the individual’s condition, severity of symptoms, and response to therapy. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

The safety of glyceryl trinitrate in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Nitrolingual Pumpspray product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nitrolingual Pumpspray is a short‑acting nitrate, offering rapid onset of action for acute chest pain, whereas other antianginals such as beta‑blockers or calcium‑channel blockers provide longer‑term control. Compared with sublingual tablets, the spray allows faster mucosal absorption and more precise dosing.

The product should be stored at room temperature, below 25 °C, in its original packaging. Keep the spray container tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

The spray is applied to the inside of the cheek or under the tongue, allowing the medication to be absorbed through the oral mucosa. Patients should hold the spray upright, actuate the pump once, and avoid swallowing immediately to ensure optimal absorption.

Serious risks include severe hypotension, syncope, and rare cases of methemoglobinemia or allergic reactions such as angioedema. Patients should be instructed to seek immediate medical attention if they experience fainting, extreme dizziness, or signs of an allergic response.

Nitrolingual Pumpspray is contraindicated in patients with known hypersensitivity to glyceryl trinitrate or other nitrates, those with severe hypotension, and individuals who have recently used phosphodiesterase‑5 inhibitors. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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