Product image of Nitrong (Glyceryl Trinitrate) supplied by GNH India

Nitrong

Active Ingredient:
Glyceryl Trinitrate
Origin:
EU

Nitrong (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitrong, is an organic nitrate presented as a transdermal patch for transdermal use. It provides vasodilation to relieve chest pain and is indicated for chronic stable angina, helping to prevent angina attacks in adult patients.

GNH India supplies Nitrong as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets. The product conforms to European Union pharmacopeial standards and is distributed under a prescription‑only framework.

Manufacturer / TM Owner

Lavipharm S.A

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Indications & Clinical Uses

Nitrong (glyceryl trinitrate) is used in the management of coronary artery disease‑related angina by providing nitric‑oxide mediated vasodilation.

  • Chronic stable angina: decreases frequency and severity of chest pain episodes.
  • Prevention of angina attacks: maintains coronary vasodilation to reduce occurrence of attacks.
  • Exercise‑induced angina: improves tolerance to physical exertion by enhancing myocardial blood flow.

How It Works

  • Glyceryl trinitrate is metabolized to nitric oxide (NO) within vascular smooth muscle cells. NO activates soluble guanylate cyclase, increasing cyclic GMP levels, which leads to relaxation of smooth muscle and vasodilation of veins and arteries, reducing preload and afterload and improving coronary blood flow. The effect is dose‑dependent and is rapidly reversible as the nitrate is cleared, allowing titration to achieve desired anti‑anginal effect without prolonged hypotension.

Side Effects

Glyceryl trinitrate may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: throbbing headache due to cerebral vasodilation.
  • Flushing: warmth and redness of the skin.
  • Dizziness: light‑headed sensation, especially on standing.
  • Hypotension: mild drop in blood pressure causing faintness.
  • Nausea: feeling of stomach upset.
  • Skin irritation at patch site: redness or itching where the patch is applied.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall leading to syncope.
  • Methemoglobinemia: elevated methemoglobin causing cyanosis.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Nitrong, clinicians should consider several precautionary measures to ensure safe use.

  • Avoid use with phosphodiesterase‑5 inhibitors: risk of severe hypotension.
  • Monitor blood pressure: watch for excessive drops after patch application.
  • Assess for anemia or low hemoglobin: may exacerbate dizziness.
  • Advise patients to change patch site daily: reduce skin irritation.
  • Contraindicated in patients with known hypersensitivity to nitrates.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Glyceryl trinitrate can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause profound hypotension.
  • Other nitrates or nitroglycerin preparations: additive vasodilatory effect leading to severe blood pressure fall.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (beta‑blockers, ACE inhibitors): may enhance blood pressure‑lowering effect.
  • Diuretics: can increase risk of orthostatic hypotension.
  • Alcohol: may potentiate vasodilatory response and dizziness.

Frequently Asked Questions

Nitrong contains glyceryl trinitrate and is prescribed to manage chronic stable angina and to prevent angina attacks. By delivering a controlled dose of nitrate through the skin, it helps reduce the frequency and severity of chest pain episodes in patients with coronary artery disease.

Glyceryl trinitrate is converted in the body to nitric oxide, which activates soluble guanylate cyclase in vascular smooth muscle. This raises cyclic GMP levels, causing smooth‑muscle relaxation and vasodilation of veins and arteries, thereby lowering cardiac workload and improving blood flow to the heart.

The appropriate dose of Nitrong is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Dosage adjustments are made during follow‑up visits, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for glyceryl trinitrate in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Nitrong.

To request Nitrong, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrong delivers glyceryl trinitrate via a transdermal patch, offering continuous nitrate exposure, whereas sublingual nitroglycerin provides rapid, short‑acting relief. Compared with oral beta‑blockers, Nitrong directly induces vasodilation without affecting heart rate, making it useful for patients who need immediate coronary blood‑flow improvement.

Store Nitrong at room temperature, preferably below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources. Do not expose the patch to extreme temperatures, and keep it out of reach of children.

Nitrong is applied to clean, dry, hair‑free skin on the upper torso or upper arm. The patch should be pressed firmly for a few seconds, and the site should be changed daily to avoid skin irritation. Patients must follow the prescriber’s schedule for wearing and removing the patch.

The most serious risks include severe hypotension, which can cause fainting or shock, and rare cases of methemoglobinemia, a condition that reduces oxygen delivery to tissues. An allergic reaction such as rash, swelling, or anaphylaxis also requires immediate medical attention.

Nitrong should not be used by individuals with known hypersensitivity to glyceryl trinitrate or other organic nitrates. It is also contraindicated in patients taking phosphodiesterase‑5 inhibitors (e.g., sildenafil) due to the risk of dangerous blood‑pressure drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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