Product image of Nitroxolin Forte Mip Pharma Polska (Nitroxoline) supplied by GNH India

Nitroxolin Forte Mip Pharma Polska

Active Ingredient:
Nitroxoline
Origin:
EU

Nitroxolin Forte Mip Pharma Polska (Nitroxoline)

Nitroxoline, the active ingredient in Nitroxolin Forte, is a quinolone derivative presented as an oral tablet for oral use. It is employed to treat urinary tract infections, including cystitis and prostatitis, in adult patients and is indicated for both uncomplicated and recurrent infections.

GNH India supplies Nitroxolin Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards, offers full regulatory documentation, and coordinates logistics to ensure reliable global delivery of this EU‑authorized antibiotic.

Manufacturer / TM Owner

Mip Pharma Polska Sp. Z O.O.

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Indications & Clinical Uses

  • Nitroxolin Forte (nitroxoline) is used in the management of bacterial infections of the urinary system.
  • Urinary tract infection (UTI): reduces bacterial load and alleviates symptoms such as dysuria and frequency.
  • Cystitis: provides targeted antimicrobial activity to resolve bladder inflammation.
  • Prostatitis: helps eradicate pathogens contributing to prostate infection and improves clinical outcomes.
  • Recurrent UTI: can be employed as a therapeutic option to prevent recurrence of infection.
  • Acute bacterial prostatitis: assists in eradicating causative organisms and reducing inflammation.

How It Works

  • Nitroxoline exerts its antibacterial effect by chelating divalent metal ions such as iron and magnesium, which are essential cofactors for bacterial enzymes. This chelation inhibits key metabolic enzymes, disrupts DNA synthesis, and impairs bacterial respiration, leading to bacteriostatic or bactericidal activity against susceptible Gram‑negative and Gram‑positive uropathogens. The drug penetrates urinary tissues and achieves high concentrations in urine, enhancing its therapeutic effect in the urinary tract.

Side Effects

Nitroxoline may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes.
  • Diarrhea: loose stools.
  • Headache: transient.
  • Dizziness: light‑headed sensation.
  • Skin rash: mild erythema.

Serious or Rare Side Effects

  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Blood dyscrasias: neutropenia or agranulocytosis.
  • Renal impairment: acute kidney injury.

Precautions & Warnings

  • When prescribing nitroxoline, clinicians should consider several safety precautions to minimize risks.
  • Renal function: assess baseline kidney function and monitor during therapy.
  • Hepatic function: evaluate liver enzymes before and during treatment.
  • Allergy: avoid use in patients with known hypersensitivity to nitroxoline or related quinolones.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk to fetus or infant.
  • Drug interactions: review concomitant medications that may affect absorption or increase toxicity.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and direct sunlight.

Avoid Interactions

Nitroxoline can interact with other medicines, altering its effectiveness or increasing adverse effects.

Major Interactions (Avoid)

  • Metal ion supplements (iron, calcium, magnesium): chelation reduces nitroxoline absorption – avoid co‑administration.
  • Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B): combined use may increase risk of renal injury.

Moderate Interactions (Monitor Closely)

  • Warfarin: nitroxoline may potentiate anticoagulant effect – monitor INR.
  • Other quinolone antibiotics: additive CNS toxicity risk – observe for seizures or confusion.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increased gastrointestinal irritation – consider gastroprotection.
  • Probenecid: may decrease renal clearance of nitroxoline – adjust dose if needed.

Frequently Asked Questions

Nitroxolin Forte contains nitroxoline, an antibacterial agent indicated for the treatment of urinary tract infections, including uncomplicated cystitis and acute bacterial prostatitis. It is prescribed to reduce bacterial load in the urinary system and relieve associated symptoms such as dysuria, frequency, and pelvic discomfort.

Nitroxoline acts by chelating essential metal ions like iron and magnesium, which are cofactors for bacterial enzymes. This chelation inhibits key metabolic pathways, disrupts DNA synthesis, and impairs bacterial respiration, resulting in bacteriostatic or bactericidal activity against susceptible uropathogens.

The dosage of Nitroxolin Forte is determined by the prescribing clinician based on the specific infection, patient age, renal function, and other clinical factors. Healthcare professionals set the appropriate strength, frequency, and duration of therapy according to current medical guidelines.

Safety data for nitroxoline in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To request Nitroxolin Forte, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nitroxolin Forte (nitroxoline) belongs to the quinolone derivative class and offers a distinct mechanism of metal‑ion chelation. Compared with agents such as trimethoprim‑sulfamethoxazole or fosfomycin, nitroxoline may retain activity against some resistant strains, but clinicians consider local susceptibility patterns, patient tolerance, and safety profiles when selecting therapy.

Nitroxolin Forte tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability. Do not use if the packaging is damaged or the tablets appear discolored.

Nitroxolin Forte is taken orally, usually with a full glass of water. It can be taken with or without food, unless the prescriber advises otherwise. Patients should follow the dosing schedule provided by their healthcare professional and complete the full course of therapy even if symptoms improve.

Serious adverse events, although rare, include hepatic dysfunction (elevated liver enzymes or hepatitis), severe allergic reactions such as anaphylaxis, blood dyscrasias like neutropenia or agranulocytosis, and acute kidney injury. Patients should seek immediate medical attention if they experience signs of liver injury, severe rash, unexplained bruising, or reduced urine output.

Nitroxolin Forte should be avoided in individuals with known hypersensitivity to nitroxoline or other quinolone derivatives. It is also contraindicated in patients with severe renal or hepatic impairment unless dose adjustments are made under specialist supervision. Children and adolescents should only use the drug if specifically prescribed, and pregnant or breastfeeding women should use it only when clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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