Product image of Nixar (Bilastine) supplied by GNH India

Nixar

Active Ingredient:
Bilastine
Origin:
EU

Nixar (Bilastine)

Bilastine, the active ingredient in Nixar, is a second‑generation H1 antihistamine presented as an ocular formulation for eye use. It is employed to relieve the symptoms of allergic conjunctivitis in patients of all ages.\n\nGNH India supplies Nixar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Bilastine acts on histamine‑mediated ocular allergy pathways to alleviate eye symptoms.\n\nAllergic conjunctivitis: reduces itching, redness and swelling of the conjunctiva.\nSeasonal allergic conjunctivitis: provides relief during pollen seasons.\nPerennial allergic conjunctivitis: controls symptoms caused by year‑round allergens.

How It Works

  • Bilastine selectively blocks peripheral H1 receptors on ocular mast cells and conjunctival tissues, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation. By inhibiting this pathway, the drug diminishes the inflammatory response and associated ocular discomfort.

Side Effects

  • Bilastine is generally well tolerated, but ocular administration can be associated with adverse reactions.\n\nCommon Side Effects:\n- Transient eye burning or stinging sensation.\n- Mild headache.\n- Temporary blurred vision.\n- Dry eye sensation.\n- Mild taste disturbance after drainage through the nasolacrimal duct.\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (anaphylaxis) with swelling of the face or throat.\n- Significant increase in intra‑ocular pressure.\n- Persistent eye pain or severe redness.\n- Vision loss or sudden visual disturbances.\n- Ocular edema or swelling of the eyelids.

Precautions & Warnings

  • Before using Nixar, consider the following safety measures.\n\nHypersensitivity: avoid if the patient has known allergy to bilastine or any excipients.\nHepatic impairment: use with caution in patients with severe liver dysfunction.\nConcurrent ocular drugs: do not combine with other antihistamine eye drops without medical advice.\nInfection monitoring: watch for signs of secondary eye infection during treatment.\nPregnancy and lactation: evaluate risk‑benefit ratio before prescribing.\nStore at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

  • Bilastine may interact with other agents that affect histamine pathways or drug metabolism.\n\nMajor Interactions (Avoid):\n- Potent CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic exposure.\n- Concurrent use of systemic H1 antihistamines can lead to additive effects.\n\nModerate Interactions (Monitor Closely):\n- Alcohol may enhance mild sedation or dizziness.\n- Other ocular decongestants may increase irritation.\n- Systemic antihistamines may increase overall antihistaminic burden.

Frequently Asked Questions

Nixar contains the antihistamine bilastine and is indicated for the treatment of allergic conjunctivitis. It helps to relieve eye itching, redness, swelling and watery discharge caused by histamine release in the conjunctiva.

Bilastine selectively blocks peripheral H1 receptors on ocular mast cells and conjunctival tissues. By preventing histamine from binding, it stops the cascade that leads to vasodilation, increased vascular permeability and nerve activation, thereby reducing inflammation and discomfort in the eye.

The prescribed dose is determined by the treating clinician. In typical practice, one drop is instilled into each affected eye once daily, but the exact regimen must follow the healthcare professional’s instructions and the product label.

Safety data for bilastine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

Enquiries can be submitted through the product page on gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Bilastine is a second‑generation H1 antagonist, offering a lower risk of sedation compared with first‑generation agents. Its high selectivity provides effective relief of allergic eye symptoms while minimizing systemic exposure, making it a preferred option for patients needing once‑daily dosing.

Store Nixar at room temperature, below 25 °C, in the original packaging. Protect the container from direct sunlight, moisture and extreme temperatures. Keep out of reach of children and do not use the product after the expiration date.

Nixar is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Close the eye gently for a few seconds to allow distribution.

Although rare, serious adverse events include severe allergic reactions such as anaphylaxis, a marked increase in intra‑ocular pressure, persistent eye pain, sudden vision changes, and significant ocular edema. Any of these symptoms require immediate medical attention.

Nixar should not be used by individuals with a known hypersensitivity to bilastine or any of the formulation’s excipients. Caution is advised in patients with severe hepatic impairment, and it should be avoided in those who have experienced severe ocular reactions to other antihistamine eye drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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