Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an azole antifungal presented as a topical formulation for skin use. It treats fungal skin infections such as athlete’s foot, ringworm and seborrheic dermatitis in adults and children, and is indicated for use on the scalp, body and intertriginous areas. The formulation is designed for once‑daily application to affected sites.

GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nizoral (ketoconazole) is used to treat superficial fungal infections affecting the skin and scalp.

  • Tinea corporis: reduces erythema and scaling caused by dermatophyte infection of the body.
  • Tinea cruris: alleviates itching and rash in the groin area due to fungal overgrowth.
  • Tinea pedis: clears foot skin infection, decreasing scaling and odor.
  • Seborrheic dermatitis: controls flaking and redness on the scalp and face.
  • Pityriasis versicolor: eliminates yeast‑induced discoloration and hyperpigmented patches.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this cytochrome P450‑dependent pathway, the drug disrupts the formation of ergosterol, an essential component of fungal cell membranes, leading to increased membrane permeability and inhibition of fungal growth. The accumulation of toxic sterol intermediates further impairs fungal metabolism, while human cells are minimally affected due to selective affinity for fungal enzymes.

Side Effects

Topical ketoconazole may cause local or systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Burning sensation: mild stinging at the application site.
  • Itching: transient pruritus on treated skin.
  • Redness: localized erythema.

Serious or Rare Side Effects

  • Allergic reaction: swelling, hives, or difficulty breathing.
  • Severe dermatitis: extensive rash or blistering.
  • Hepatotoxicity: rare systemic absorption leading to liver enzyme elevation.

Precautions & Warnings

Before using Nizoral, consider the following safety measures to minimize risks.

  • Avoid use on broken skin: apply only to intact epidermis.
  • Limit duration: do not exceed recommended treatment period without medical advice.
  • Monitor for irritation: discontinue if severe burning or rash develops.
  • Caution in liver disease: inform healthcare provider of existing hepatic conditions.
  • Pregnancy and lactation: discuss risks with a physician before use.
  • Store below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole can affect the activity of other medicines; interactions are classified by clinical significance.

Major Interactions (Avoid)

  • Systemic antifungals: concurrent use may increase risk of hepatotoxicity.
  • CYP3A4 substrates: topical ketoconazole may modestly increase plasma levels of drugs metabolized by CYP3A4, such as certain statins.
  • Hormonal contraceptives: may reduce efficacy, requiring additional contraceptive measures.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may enhance skin absorption, increasing local irritation.
  • Warfarin: monitor INR as ketoconazole can affect anticoagulant metabolism.
  • Antiretrovirals: observe for altered levels of protease inhibitors.

Frequently Asked Questions

Nizoral is indicated for the topical treatment of superficial fungal infections such as tinea corporis (body ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), seborrheic dermatitis of the scalp and face, and pityriasis versicolor, a yeast‑induced discoloration of the skin.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption increases membrane permeability, halts fungal growth, and leads to the death of the offending organism.

The dosage and frequency of Nizoral are determined by a qualified prescriber based on the specific infection, severity, patient age, and treatment guidelines. Patients should follow the healthcare professional’s instructions and not alter the regimen on their own.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their physician before using Nizoral.

To request Nizoral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nizoral belongs to the azole class of antifungals, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole has a similar efficacy for many skin infections but may be preferred when a single‑agent topical formulation is desired for scalp and body use.

Store Nizoral below 25 °C in its original container, protecting it from moisture, heat and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures that could compromise its stability.

Apply a thin layer of the cream or lotion to the affected skin area once daily, or as directed by the prescriber. Gently rub it in until it disappears, and wash hands after application to prevent accidental contact with eyes or mucous membranes.

Although rare, serious adverse reactions can include severe allergic responses such as swelling, hives, or difficulty breathing, extensive dermatitis or blistering, and systemic hepatotoxicity manifested by abnormal liver enzymes. Any of these symptoms require immediate medical attention.

Individuals with known hypersensitivity to ketoconazole or any component of the formulation should avoid Nizoral. Patients with extensive broken skin, severe liver disease, or those taking interacting medications without medical supervision should also consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Ketoconazole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT