Nizoral (Ketoconazole)

Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in the synthesis of ergosterol, an essential component of fungal cell membranes. By blocking ergosterol production, the drug disrupts membrane integrity, leading to increased permeability and fungal cell death.

The specific dose and frequency are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and treatment guidelines. Typically, a thin layer of the cream or shampoo is applied to the affected area once or twice daily for the prescribed duration.

Safety data for topical ketoconazole in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with allylamine agents such as terbinafine, ketoconazole has a broader spectrum against dermatophytes and yeasts but may cause more local irritation. It is often chosen for its efficacy against Malassezia species in seborrheic dermatitis, whereas terbinafine is preferred for nail infections due to better nail penetration.

Nizoral should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid freezing. Ensure the lid is tightly closed after each use to maintain stability.

For cream or lotion forms, clean and dry the affected skin, then apply a thin layer to the lesion and surrounding area, gently rubbing it in. For shampoo, wet the scalp, massage the product into the hair and skin, leave for several minutes, then rinse thoroughly. Follow the prescriber’s instructions regarding frequency and duration.

Although rare, serious adverse reactions can include severe allergic skin reactions such as Stevens‑Johnson syndrome, toxic epidermal necrolysis, or widespread contact dermatitis. Systemic absorption may rarely lead to hepatic dysfunction or adrenal suppression, especially with extensive use. Discontinue use and seek medical attention if severe rash, blistering, or jaundice occurs.

Nizoral should be avoided in individuals with a known hypersensitivity to ketoconazole, other azole antifungals, or any component of the formulation. It is also not recommended for use on large areas of damaged or inflamed skin, on mucous membranes, or in patients with uncontrolled hepatic disease without medical supervision.