Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an imidazole antifungal presented as a topical formulation for skin use. It is employed to treat fungal infections of the skin and scalp, particularly in adults and children when prescribed by a healthcare professional.

GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable global logistics. Our distribution network ensures timely delivery and adherence to local import requirements.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Ketoconazole is used topically to treat a range of superficial fungal infections of the skin.

  • Tinea corporis: reduces fungal growth and promotes clearance of body ringworm lesions.
  • Tinea cruris: alleviates itching and eliminates the fungal cause of jock itch.
  • Tinea pedis: improves foot skin condition by eradicating dermatophyte infection.
  • Seborrheic dermatitis: controls yeast‑related scalp inflammation and scaling.
  • Pityriasis versicolor: restores normal skin pigmentation by eliminating Malassezia species.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a cytochrome P450 isoform essential for converting lanosterol to ergosterol. By blocking ergosterol synthesis, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death. This mechanism is selective for fungi, minimizing effects on human cells.

Side Effects

Topical ketoconazole may cause local skin reactions, ranging from mild irritation to rare severe events.

Common Side Effects

  • Itching: mild pruritus at the application site.
  • Burning sensation: transient heat feeling during or after use.
  • Redness: localized erythema around the treated area.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or breathing difficulty.
  • Severe skin rash: widespread dermatitis or bullous eruptions.
  • Hepatic toxicity: rare systemic absorption causing liver enzyme elevation.

Precautions & Warnings

When using topical ketoconazole, observe the following precautions to ensure safe and effective treatment.

  • Avoid application on broken or inflamed skin: may increase irritation or systemic absorption.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Keep away from eyes and mucous membranes: rinse thoroughly if contact happens.
  • Do not use with other topical antifungals unless directed: risk of additive irritation.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole can interact with other medicines, especially when systemic absorption is possible.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): may increase ketoconazole levels and toxicity.
  • Oral antifungal agents (e.g., terbinafine): concurrent use can raise risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Warfarin: ketoconazole may enhance anticoagulant effect, monitor INR.
  • Hormonal contraceptives: efficacy may be reduced, advise alternative contraception.
  • Topical steroids: may mask irritation, assess skin response regularly.

Frequently Asked Questions

Nizoral is a prescription‑only topical cream that treats superficial fungal skin infections such as tinea corporis (body ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), seborrheic dermatitis (scalp dandruff) and pityriasis versicolor (skin discoloration).

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption increases membrane permeability, leading to fungal cell death and clearance of the infection.

The dosage of Nizoral is determined by the prescribing clinician based on the infection type, severity, patient age and skin area involved. The prescriber will specify the amount to apply and the frequency of application.

Safety data for topical ketoconazole in pregnancy and lactation are limited. It is classified as pregnancy category unknown, so clinicians should weigh potential benefits against risks and discuss alternatives with the patient.

To order Nizoral, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nizoral (ketoconazole) belongs to the imidazole class, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine creams such as terbinafine, ketoconazole may be preferred for seborrheic dermatitis and Malassezia‑related conditions, while terbinafine is often chosen for nail infections.

Store Nizoral at ambient temperature, preferably below 25 °C. Keep the tube in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed when not in use.

Clean and dry the affected skin area, then apply a thin layer of Nizoral to the lesion once or twice daily as directed by the prescriber. Gently rub it in until it disappears, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

Although rare, serious adverse events include severe allergic reactions (hives, swelling, breathing difficulty), extensive skin rash or bullous eruptions, and systemic hepatic toxicity if significant absorption occurs. Any signs of these reactions require immediate medical attention.

Nizoral should be avoided in individuals with known hypersensitivity to ketoconazole or any imidazole antifungal. It is also contraindicated on severely damaged, ulcerated or inflamed skin where systemic absorption could be increased.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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