Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an azole antifungal presented as a topical formulation for skin application. It is used to treat fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis and pityriasis versicolor.
GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ketoconazole acts on dermatophyte and yeast infections of the skin, reducing fungal growth and associated inflammation.

  • Tinea corporis: clears ring‑shaped fungal lesions on the body.
  • Tinea cruris: relieves itching and redness in the groin area.
  • Tinea pedis: treats athlete’s foot and reduces scaling.
  • Seborrheic dermatitis: diminishes flaking and erythema on scalp and face.
  • Pityriasis versicolor: eliminates discolored patches caused by Malassezia species.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby controlling the infection.

Side Effects

Topical ketoconazole is generally well tolerated, but local reactions can occur.

Common Side Effects

  • Burning sensation: mild to moderate heat at the application site.
  • Itching: transient pruritus during treatment.
  • Skin irritation: redness or mild inflammation.
  • Dryness: temporary loss of moisture on treated skin.
  • Peeling: superficial desquamation as the lesion resolves.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe rash, swelling, or hives.
  • Stevens‑Johnson syndrome: rare but life‑threatening skin reaction.
  • Systemic absorption leading to hepatotoxicity: elevated liver enzymes in susceptible individuals.
  • Severe photosensitivity: exaggerated sunburn response.
  • Anaphylaxis: acute, potentially fatal hypersensitivity reaction.

Precautions & Warnings

Before using topical ketoconazole, consider the following safety measures.

  • Avoid application on broken or inflamed skin: may increase systemic absorption.
  • Keep away from eyes and mucous membranes: can cause irritation.
  • Discontinue if severe irritation or allergic reaction occurs: seek medical advice.
  • Do not use with other topical irritants or corticosteroids unless directed.
  • Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole can interact with other medications, especially when systemic absorption is possible.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole oral, itraconazole): may increase systemic ketoconazole levels.
  • Warfarin: enhanced anticoagulant effect, monitor INR closely.
  • Oral contraceptives: reduced efficacy, consider alternative contraception.

Moderate Interactions (Monitor Closely)

  • Other topical antifungals: risk of additive irritation.
  • Systemic steroids: may mask signs of infection.
  • Antihistamines: possible increased sedation if systemic exposure occurs.

Frequently Asked Questions

Nizoral is a topical antifungal indicated for skin infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), seborrheic dermatitis (scalp and facial flaking), and pityriasis versicolor (discolored patches). It works by eliminating the fungi responsible for these conditions.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes unstable, leading to cell leakage and death of the fungus.

The specific amount and frequency of Nizoral application are determined by the prescribing healthcare professional based on the infection type, severity, and patient factors. Patients should follow the prescriber’s instructions and not alter the regimen on their own.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Healthcare providers usually weigh potential benefits against risks before prescribing. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their clinician.

To request Nizoral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nizoral (ketoconazole) belongs to the azole class, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents like terbinafine, azoles may have a slightly slower onset but are effective for a wide range of skin infections and are often chosen for seborrheic dermatitis due to anti‑inflammatory properties.

Store Nizoral at temperatures below 25 °C in its original packaging. Protect the product from moisture, direct sunlight and extreme heat to maintain stability and potency throughout its shelf life.

Apply a thin layer of the cream or lotion to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands after application to avoid accidental contact with eyes or other mucous membranes.

Although rare, serious adverse reactions can include severe allergic dermatitis, Stevens‑Johnson syndrome, systemic hepatotoxicity from significant absorption, and anaphylaxis. Patients should stop use and seek immediate medical attention if they experience widespread rash, blistering, fever, or signs of liver dysfunction.

Individuals with known hypersensitivity to ketoconazole or any component of the formulation should avoid Nizoral. It is also contraindicated on extensive broken skin, open wounds, or in patients with a history of severe drug reactions without prior medical evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Ketoconazole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT