Nizoral (Ketoconazole)

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes defective, leading to cell leakage and death of the fungus.

The dosage of Nizoral is determined by the prescribing clinician based on the infection type, severity, and patient factors. The prescriber will specify the amount of cream to apply, the frequency, and the duration of therapy.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Nizoral.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazole offers broad‑spectrum activity against dermatophytes and yeasts and is applied topically, which limits systemic exposure. Compared with allylamine agents such as terbinafine, ketoconazole may be preferred for seborrheic dermatitis, while terbinafine is often chosen for nail infections due to its longer half‑life.

Store Nizoral at room temperature, preferably below 25 °C. Keep the tube in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain product stability.

Apply a thin layer of the cream to the affected skin area, usually twice daily, unless otherwise directed by a healthcare professional. Gently rub it in until fully absorbed, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

While rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and significant liver toxicity if systemic absorption occurs. Patients should seek immediate medical attention if they notice widespread rash, blistering, or signs of liver dysfunction.

Individuals with a known hypersensitivity to ketoconazole, other azole antifungals, or any component of the formulation should avoid using Nizoral. It is also contraindicated on severely damaged or inflamed skin until the underlying condition is resolved.