Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is a azole antifungal presented as a cream for topical skin use. It treats fungal infections of the skin and scalp in adults and children as directed by a healthcare professional.

GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Ketoconazole is an azole antifungal used to treat superficial fungal skin conditions.

  • Tinea corporis: reduces redness, scaling and clears the ring‑shaped rash.
  • Tinea cruris: alleviates itching and clears fungal infection in the groin area.
  • Tinea pedis: treats athlete’s foot by eliminating the causative dermatophytes.
  • Seborrheic dermatitis: controls flaking and inflammation of the scalp and face.
  • Pityriasis versicolor: restores normal skin pigmentation by eradicating yeast overgrowth.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Disruption of ergosterol production compromises the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby resolving the infection on the skin surface.

Side Effects

Ketoconazole cream may cause local skin reactions.

Common Side Effects

  • Itching: mild to moderate sensation of itch at the application site.
  • Burning: transient warmth or stinging after application.
  • Redness: localized erythema.
  • Dryness: skin may feel less moist.
  • Scaling: flaking of the treated area.
  • Irritation: general discomfort or tenderness.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or difficulty breathing.
  • Severe dermatitis: extensive rash or blistering.
  • Stevens‑Johnson syndrome: rare but serious skin disorder.
  • Systemic toxicity: unlikely but possible liver enzyme elevation with extensive use.

Precautions & Warnings

Before using ketoconazole cream, consider the following safety measures.

  • Avoid use on broken or inflamed skin: may increase irritation.
  • Keep away from eyes and mucous membranes: avoid accidental contact.
  • Discontinue if severe irritation occurs: seek medical advice.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Keep out of reach of children: prevent accidental ingestion.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole topical has limited systemic interactions, but caution is advised.

Major Interactions (Avoid)

  • Concurrent use with other topical azoles: may increase local irritation.
  • Systemic azole antifungals: potential additive systemic absorption.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask signs of irritation or infection.
  • Skin care products containing alcohol or astringents: could enhance dryness.
  • Phototoxic agents: increase risk of sun‑related skin reactions.

Frequently Asked Questions

Nizoral, containing ketoconazole, is applied to the skin to treat fungal infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis, and pityriasis versicolor. It works by eliminating the fungi that cause these conditions, helping to reduce symptoms like redness, itching, and scaling.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes unstable, leading to fungal cell death and clearance of the infection.

The dosage of Nizoral cream is determined by the prescribing healthcare professional based on the specific condition, severity, and patient factors. Patients should follow the instructions provided on the prescription label and consult their clinician for any questions.

Pregnant or breastfeeding individuals should discuss the use of Nizoral with their healthcare provider. While topical ketoconazole generally has limited systemic absorption, a clinician can evaluate the potential risks and benefits for each specific case.

To request Nizoral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nizoral (ketoconazole) belongs to the azole class, which inhibits fungal ergosterol synthesis. Compared with allylamine agents such as terbinafine, azoles have a broader spectrum against yeasts and dermatophytes but may cause more local irritation. Choice of therapy depends on the infection type, patient tolerance, and clinician preference.

Store Nizoral cream at room temperature, below 25 °C. Keep the tube in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain product stability.

Apply a thin layer of Nizoral cream to the affected skin area once or twice daily, as directed by a healthcare professional. Gently rub it in until fully absorbed, and wash hands before and after application to avoid spreading the medication.

Serious risks, though rare, include severe allergic reactions such as hives, swelling, or difficulty breathing, and severe skin reactions like Stevens‑Johnson syndrome. If any of these occur, discontinue use immediately and seek urgent medical attention.

Individuals with known hypersensitivity to ketoconazole or any component of the formulation should avoid Nizoral. It should also be used with caution in patients with extensive broken skin, and it is not recommended for use on the scalp of children under 12 without specific medical advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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