Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an azole antifungal presented as a topical preparation for skin use. It is employed to treat a range of superficial fungal infections in adults and children, targeting the causative dermatophytes and yeasts on the skin surface.

GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Thornton & Ross Ltd

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Indications & Clinical Uses

Ketoconazole is used topically to manage fungal skin conditions by inhibiting the growth of dermatophytes and yeasts.

  • Athlete’s foot (tinea pedis): reduces itching and clears infection on the feet.
  • Jock itch (tinea cruris): alleviates redness and eliminates the fungal cause in the groin area.
  • Ringworm (tinea corporis): treats circular lesions on the body by eradicating the pathogen.
  • Seborrheic dermatitis: controls flaking and inflammation on the scalp and face.
  • Pityriasis versicolor: clears discolored patches caused by Malassezia species.

How It Works

  • Ketoconazole inhibits fungal sterol (ergosterol) synthesis by blocking the cytochrome P450 enzyme lanosterol 14α‑demethylase. This disruption compromises the fungal cell membrane, leading to impaired growth and eventual cell death of dermatophytes and yeasts on the skin surface.

Side Effects

Topical ketoconazole may cause local and, rarely, systemic reactions.

Common Side Effects

  • Skin irritation: mild redness or burning at the application site.
  • Itching: transient pruritus.
  • Dryness: localized skin dryness.
  • Scaling: mild flaking.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Contact dermatitis: intense rash or blistering requiring medical attention.

Precautions & Warnings

When using Nizoral, consider the following safety measures.

  • Avoid use on broken skin: may increase systemic absorption.
  • Do not apply to eyes or mucous membranes: can cause irritation.
  • Limit treatment duration: prolonged use may lead to resistance.
  • Discontinue if severe irritation occurs: seek medical advice.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., itraconazole): concurrent use may increase systemic ketoconazole exposure.
  • Strong CYP3A4 inhibitors (e.g., clarithromycin): may elevate plasma levels if absorbed.

Moderate Interactions (Monitor Closely)

  • Warfarin: topical use may potentiate anticoagulant effect; monitor INR.
  • Oral contraceptives: potential reduction in efficacy; consider alternative contraception.
  • Other topical irritants (e.g., corticosteroids): may increase skin irritation; observe for adverse reactions.

Frequently Asked Questions

Nizoral is indicated for the topical treatment of superficial fungal skin infections such as athlete’s foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis), seborrheic dermatitis, and pityriasis versicolor caused by dermatophytes or yeasts.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Without ergosterol, the fungal cell membrane becomes defective, inhibiting growth and leading to cell death of the infecting organism.

The amount of Nizoral applied and the duration of therapy are set by the prescribing healthcare professional based on the type and severity of the infection, patient age, and response to treatment.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks with their physician before using Nizoral.

To order Nizoral, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nizoral (ketoconazole) belongs to the azole class and offers broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole may be preferred for seborrheic dermatitis and Malassezia‑related conditions, while terbinafine is often chosen for nail infections.

Store Nizoral at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and effectiveness.

Clean and dry the affected skin area, then apply a thin layer of Nizoral to the lesion once or twice daily as directed by the prescriber. Wash hands after application and avoid covering the treated area with occlusive dressings unless instructed.

Although rare, serious risks include severe allergic reactions such as swelling, hives, or difficulty breathing, and contact dermatitis presenting as intense rash or blistering. Immediate medical attention is required if these symptoms develop.

Individuals with known hypersensitivity to ketoconazole or any component of the formulation should avoid Nizoral. It should also be used with caution on extensively broken skin or in patients with a history of severe skin reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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