Product image of Nizoral (Ketoconazole) supplied by GNH India

Nizoral

Active Ingredient:
Ketoconazole
Origin:
EU

Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is a azole antifungal presented as a topical formulation for skin use. It is employed to treat fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis and pityriasis versicolor in patients requiring topical therapy.

GNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Thornton & Ross Ltd

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Indications & Clinical Uses

Ketoconazole is an azole antifungal that acts on dermatophyte and yeast infections of the skin.

  • Tinea corporis: reduces fungal growth and clears the ring‑shaped rash.
  • Tinea cruris: alleviates itching and erythema in the groin area.
  • Tinea pedis: eliminates foot fungus and prevents recurrence.
  • Seborrheic dermatitis: controls flaking and redness on scalp and face.
  • Pityriasis versicolor: restores normal skin pigmentation by eradicating Malassezia species.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death. This mechanism is selective for fungi, sparing human cells that use cholesterol instead of ergosterol.

Side Effects

Topical ketoconazole may cause local skin reactions.

Common Side Effects

  • Burning sensation at the application site
  • Itching or pruritus
  • Mild irritation or redness
  • Dryness or peeling of the skin
  • Contact dermatitis
  • Stinging feeling after application

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Extensive swelling or edema of the treated area
  • Widespread rash or blistering
  • Persistent severe irritation requiring medical attention

Precautions & Warnings

Before using Nizoral, consider the following safety measures.

  • Avoid use on broken or inflamed skin: apply only to intact areas.
  • Do not apply near eyes, mouth or mucous membranes: risk of irritation.
  • Discontinue if severe irritation or allergic reaction occurs: seek medical advice.
  • Pregnant or breastfeeding individuals should consult a healthcare professional before use.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole topical has limited systemic absorption, but certain interactions should be noted.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals containing the same active ingredient: may increase irritation risk.
  • Application over large areas combined with systemic azole therapy: could enhance systemic exposure.

Moderate Interactions (Monitor Closely)

  • Use with corticosteroid creams: may mask signs of infection.
  • Use with skin irritants or harsh soaps: could exacerbate local reactions.
  • Systemic medications metabolized by CYP450 enzymes: monitor if extensive skin application leads to measurable absorption.

Frequently Asked Questions

Nizoral, containing ketoconazole, is used to treat superficial fungal skin infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), seborrheic dermatitis (scalp flaking), and pityriasis versicolor (skin discoloration). It works as a topical antifungal to eliminate the causative fungi and relieve associated symptoms.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes defective, leading to increased permeability and fungal cell death. This targeted action reduces the infection while sparing human cells.

The specific amount, frequency, and duration of Nizoral application are determined by the prescribing healthcare professional based on the infection type, severity, and patient factors. Patients should follow the prescriber's instructions and the product labeling for optimal results.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Nizoral.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Nizoral (ketoconazole) is an azole antifungal, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole may have a slightly slower onset but is effective for a wide range of skin infections. Choice of therapy depends on infection type, resistance patterns, patient tolerance and clinician preference.

Nizoral should be stored at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain stability.

Apply a thin layer of the cream or lotion to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands after application. Avoid covering the treated area with occlusive dressings unless instructed.

While uncommon, serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience widespread rash, blistering, swelling, or difficulty breathing after using the product.

Individuals with known hypersensitivity to ketoconazole, other azole antifungals, or any component of the formulation should avoid Nizoral. It should also not be used on extensive broken skin, mucous membranes, or in patients where a prescriber determines the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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