Product image of No-Spa (Drotaverine Hydrochloride) supplied by GNH India

No-Spa

Active Ingredient:
Drotaverine Hydrochloride
Origin:
EU

No-Spa (Drotaverine Hydrochloride)

Drotaverine Hydrochloride, the active ingredient in No-Spa, is a phosphodiesterase‑4 inhibitor presented as an oral tablet for oral use. It relaxes smooth muscle in the gastrointestinal, biliary and urinary tracts and is used to relieve spasmodic pain in adults. No-Spa is available over‑the‑counter in the European market and is supplied without a prescription.

GNH India supplies No-Spa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Commercial Kft.

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Indications & Clinical Uses

No-Spa (drotaverine) acts on smooth‑muscle spasm disorders in the gastrointestinal, biliary and urinary systems. It is indicated for:

  • Abdominal and gastrointestinal spasm: Relieves painful contractions of the intestinal wall.
  • Dysmenorrhea: Reduces uterine muscle cramps associated with menstrual pain.
  • Biliary colic: Alleviates spasm of the biliary ducts causing upper‑right abdominal discomfort.
  • Urinary tract spasm: Eases bladder and ureteral smooth‑muscle contractions.
  • Renal colic: Mitigates kidney‑related smooth‑muscle pain.

How It Works

  • Drotaverine selectively inhibits phosphodiesterase‑4, leading to an accumulation of intracellular cyclic AMP. Elevated cAMP causes relaxation of smooth muscle by reducing calcium influx, which diminishes contractility in the gastrointestinal, biliary and urinary tracts, thereby relieving spasm and associated pain.

Side Effects

Adverse reactions may occur with any medication. Common Side Effects:

  • Dry mouth: Reduced salivary secretion.
  • Dizziness: Transient light‑headedness.
  • Headache: Mild to moderate pain.
  • Nausea: Stomach discomfort.
  • Flushing: Warm sensation of the skin.
  • Hypotension: Slight drop in blood pressure.

Serious or Rare Side Effects

  • Allergic reaction: Rash, itching, swelling.
  • Severe hypotension: Marked blood pressure fall.
  • Tachycardia: Rapid heart rate.
  • Hepatic dysfunction: Elevated liver enzymes.
  • Blood dyscrasias: Unusual bleeding or bruising.
  • Anaphylaxis: Life‑threatening systemic reaction.

Precautions & Warnings

Before using No‑Spa, consider the following safety points.

  • Pregnancy: Use only if clearly needed, as safety data are limited.
  • Breastfeeding: Weigh potential benefits against unknown infant exposure.
  • Cardiovascular disease: Monitor blood pressure and heart rate.
  • Liver impairment: Use with caution; dose adjustment may be required.
  • Elderly patients: Start with the lowest effective dose and observe tolerance.
  • Store at ambient temperature: Keep below 25 °C, in the original packaging, protected from moisture.

Avoid Interactions

Drug interactions may modify the effect of No‑Spa.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase drotaverine plasma levels.
  • Other antispasmodics: Additive smooth‑muscle relaxation can cause excessive hypotension.
  • Antihypertensive agents: Potential for enhanced blood‑pressure lowering.

Moderate Interactions (Monitor Closely)

  • Alcohol: May intensify dizziness and hypotension.
  • Central nervous system depressants: Observe for increased sedation.
  • Diuretics: Monitor electrolyte balance and blood pressure.

Frequently Asked Questions

No‑Spa contains drotaverine hydrochloride and is used to relieve smooth‑muscle spasms in the abdomen, biliary system, urinary tract and kidneys, as well as menstrual cramps. It helps reduce pain associated with these spasmodic conditions.

Drotaverine selectively blocks phosphodiesterase‑4, which raises intracellular cyclic AMP levels. The increased cAMP relaxes smooth muscle by decreasing calcium entry, leading to reduced contractility and relief of spasm in the gastrointestinal, biliary and urinary tracts.

The appropriate dose of No‑Spa is determined by a qualified prescriber based on the patient’s condition, age, weight and overall health. Patients should follow the dosing instructions provided by their healthcare professional.

Safety data for drotaverine in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with anticholinergic antispasmodics, drotaverine does not have strong anticholinergic side effects such as dry eyes or urinary retention. Its phosphodiesterase‑4 inhibition provides smooth‑muscle relaxation with a generally favorable tolerability profile.

No‑Spa tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

No‑Spa is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious but rare risks include severe allergic reactions, marked hypotension, rapid heart rate, liver enzyme elevations and blood‑cell abnormalities. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, faintness, rapid heartbeat or unusual bruising.

No‑Spa is contraindicated in individuals with known hypersensitivity to drotaverine or any excipients in the tablet. Caution is advised for patients with severe cardiovascular disease, uncontrolled hypertension, or significant liver impairment, and it should be avoided in such cases unless a physician determines it is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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