Product image of No-Spa Max (Drotaverine Hydrochloride) supplied by GNH India

No-Spa Max

Active Ingredient:
Drotaverine Hydrochloride
Origin:
EU

No-Spa Max (Drotaverine Hydrochloride)

Drotaverine Hydrochloride, the active ingredient in No‑Spa Max, is an antispasmodic (phosphodiesterase‑4 inhibitor) presented as an oral tablet for oral use. It is employed to relieve smooth‑muscle spasm‑related pain such as abdominal discomfort, menstrual cramps and urinary colic.

GNH India supplies No‑Spa Max as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU quality standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Opella Healthcare Commercial Kft.

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Indications & Clinical Uses

Drotaverine Hydrochloride acts as a smooth‑muscle relaxant and is indicated for conditions involving spasm of the gastrointestinal, genitourinary and vascular systems.

  • Abdominal pain: reduces cramping and discomfort caused by intestinal spasms.
  • Menstrual cramps: alleviates uterine muscle contractions during dysmenorrhea.
  • Urinary colic: eases painful spasms of the urinary tract associated with renal colic or bladder obstruction.

How It Works

  • Drotaverine selectively inhibits phosphodiesterase‑4, leading to an increase in intracellular cyclic AMP. Elevated cAMP reduces calcium influx in smooth‑muscle cells, causing relaxation of gastrointestinal, genitourinary and vascular smooth muscle and thereby diminishing spasm‑related pain.

Side Effects

Adverse reactions may occur with any antispasmodic medication.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Nausea: occasional upset stomach.
  • Dry mouth: reduced salivation.
  • Flushing: brief warmth or redness of the skin.
  • Gastro‑intestinal discomfort: mild abdominal upset.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Severe hypotension: sudden drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Hematologic abnormalities: rare blood count changes.

Precautions & Warnings

Before using No‑Spa Max, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Liver impairment: use with caution; monitor hepatic function.
  • Renal impairment: dose adjustment may be required.
  • Concomitant antihypertensives: monitor blood pressure for additive effects.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Drotaverine may interact with other medicines; awareness of potential interactions helps ensure safe use.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase drotaverine plasma levels.
  • Antihypertensive agents: additive blood‑pressure‑lowering effect.

Moderate Interactions (Monitor Closely)

  • Other antispasmodics: risk of excessive smooth‑muscle relaxation.
  • Diuretics: monitor electrolyte balance.
  • Anticholinergic drugs: possible enhanced anticholinergic side effects.

Frequently Asked Questions

No‑Spa Max contains drotaverine hydrochloride, an antispasmodic that is used to relieve smooth‑muscle spasm‑related pain. It is commonly prescribed for abdominal cramps, menstrual dysmenorrhea and urinary colic caused by spasms of the urinary tract.

Drotaverine selectively blocks phosphodiesterase‑4, which raises intracellular cyclic AMP levels. The increased cAMP reduces calcium entry into smooth‑muscle cells, leading to relaxation of gastrointestinal, uterine and urinary tract muscles and thereby decreasing spasm‑related discomfort.

The appropriate dose of No‑Spa Max is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and overall health. Patients should follow the exact dosing instructions provided by their doctor or pharmacist.

Safety data for drotaverine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using No‑Spa Max.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional anticholinergic antispasmodics, drotaverine has a distinct mechanism as a phosphodiesterase‑4 inhibitor, offering smooth‑muscle relaxation without strong anticholinergic effects. This can result in a different side‑effect profile, often with fewer dry‑mouth or urinary‑retention issues.

No‑Spa Max should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture, excessive heat and direct sunlight to maintain product stability.

No‑Spa Max is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed unless directed otherwise by a healthcare professional.

Serious adverse reactions, though rare, include severe allergic responses such as rash, swelling or breathing difficulty, marked hypotension, cardiac arrhythmias and significant liver enzyme elevations. Patients should seek immediate medical attention if any of these symptoms occur.

Individuals with known hypersensitivity to drotaverine or any excipients in the tablet should not use No‑Spa Max. Caution is also advised for patients with severe liver or kidney impairment, uncontrolled hypertension, or those taking medications that may cause major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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