Product image of Noan (Diazepam) supplied by GNH India

Noan

Active Ingredient:
Diazepam
Origin:
EU

Noan (Diazepam)

Diazepam, the active ingredient in Noan, is a benzodiazepine presented as an oral tablet for oral use. It is employed to treat anxiety disorders, seizure disorders, muscle spasm, alcohol withdrawal and to provide sedation in adult patients.

GNH India supplies Noan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Diazepam is a benzodiazepine that acts on the central nervous system to manage several conditions.

  • Anxiety disorders: reduces excessive anxiety and promotes calmness.
  • Seizure disorders: helps control various types of seizures.
  • Muscle spasm: relaxes skeletal muscle tone.
  • Alcohol withdrawal: alleviates tremor, agitation and risk of seizures.
  • Sedation: provides short‑term sedation for procedural or diagnostic purposes.

How It Works

  • Diazepam acts as a positive allosteric modulator of the GABA‑A receptor complex. By binding to a distinct site on the receptor, it enhances the inhibitory effect of the neurotransmitter GABA, increasing chloride ion influx, hyperpolarising neuronal membranes and thereby decreasing neuronal excitability throughout the central nervous system.

Side Effects

Diazepam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Muscle weakness
  • Impaired coordination
  • Dizziness
  • Headache

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypotension
  • Paradoxical reactions such as agitation or aggression
  • Dependence and withdrawal syndrome
  • Depression or suicidal thoughts
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)

Precautions & Warnings

Before prescribing Noan, clinicians should consider several safety factors.

  • Pregnancy: category D; avoid unless benefits outweigh risks.
  • Elderly patients: increased sensitivity; start with the lowest effective dose.
  • History of substance abuse: heightened risk of dependence; monitor closely.
  • Concurrent CNS depressants: may amplify sedation and respiratory effects.
  • Operating machinery: avoid until the individual’s response to the drug is known.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Diazepam can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Opioids: additive respiratory depression.
  • Alcohol: enhanced sedative effect.
  • CYP3A4 inhibitors (e.g., ketoconazole): increased diazepam plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., carbamazepine): reduced effectiveness.
  • Antidepressants (SSRIs): may increase sedation.
  • Antihistamines: additive drowsiness.

Frequently Asked Questions

Noan contains diazepam, a benzodiazepine indicated for the short‑term relief of anxiety disorders, control of various seizure types, relief of muscle spasm, management of alcohol‑withdrawal symptoms, and provision of sedation for diagnostic or therapeutic procedures.

Diazepam binds to a specific site on the GABA‑A receptor complex, acting as a positive allosteric modulator. This enhances the inhibitory action of GABA, increasing chloride influx into neurons, which hyperpolarises the cell membrane and reduces neuronal firing throughout the central nervous system.

The appropriate dose of Noan is determined by the prescribing clinician based on the patient’s age, clinical condition, response to therapy and any concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions.

Diazepam is classified as pregnancy category D, indicating evidence of risk to the fetus. It should be used during pregnancy only if the potential benefit justifies the risk. Breastfeeding is not recommended because diazepam passes into milk and may affect the infant.

To request Noan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Noan (diazepam) has a relatively long half‑life compared with agents such as lorazepam or alprazolam, providing smoother plasma levels but a higher potential for accumulation. Its broad indication profile makes it useful for both anxiety and seizure control, whereas some alternatives are more selective for one therapeutic area.

Store Noan at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablet appears discoloured.

Noan is supplied as an oral tablet and should be taken by mouth with a glass of water. It may be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels.

The most serious risks include respiratory depression, especially when combined with other CNS depressants, severe hypotension, paradoxical reactions such as agitation or aggression, development of physical dependence, and the potential for withdrawal seizures if the medication is stopped abruptly.

Noan is contraindicated in patients with acute narrow‑angle glaucoma, severe respiratory insufficiency, myasthenia gravis, severe hepatic impairment, and in individuals who have shown hypersensitivity to diazepam or any benzodiazepine component.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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