Product image of Nobixal (Tianeptine Sodium) supplied by GNH India

Nobixal

Active Ingredient:
Tianeptine Sodium
Origin:
EU

Nobixal (Tianeptine Sodium)

Tianeptine Sodium, the active ingredient in Nobixal, is an atypical antidepressant presented as an oral formulation for systemic use. It is indicated for the treatment of major depressive disorder in adult patients and works by modulating serotonergic and glutamatergic pathways.

GNH India supplies Nobixal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for importers. It offers batch‑specific certificates of analysis and supports cold‑chain logistics where required.

Manufacturer / TM Owner

Antibiotice Sa

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Indications & Clinical Uses

  • Nobixal is an atypical antidepressant used within the depressive disorder therapeutic area.
  • Major depressive disorder: reduces core depressive symptoms and improves functional capacity in adults.
  • Depressive episodes associated with major depressive disorder: helps alleviate mood disturbances during acute phases.
  • Recurrent major depressive disorder: supports maintenance of remission and reduces relapse risk.

How It Works

  • Tianeptine Sodium enhances the reuptake of serotonin, leading to increased serotonergic signaling, while simultaneously modulating glutamatergic transmission. This dual action influences neuroplasticity and stress‑related neural circuits, contributing to its antidepressant effect without the classic monoamine‑reuptake inhibition seen in many other agents.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal discomfort.
  • Headache: transient tension‑type headaches.
  • Dizziness: occasional light‑headedness.
  • Dry mouth: reduced salivation.
  • Constipation: slowed bowel movements.
  • Insomnia: difficulty initiating sleep.

Serious or Rare Side Effects

  • Suicidal ideation: emergence or worsening of suicidal thoughts.
  • Severe liver injury: elevated transaminases or hepatic failure.
  • Pancreatitis: acute abdominal pain with elevated enzymes.
  • Anaphylactic reaction: rapid onset of swelling, rash, and respiratory distress.
  • Seizures: convulsive episodes, particularly in predisposed individuals.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion in milk; caution advised.
  • Renal impairment: adjust use and monitor renal function.
  • History of seizures: monitor closely for neurological events.
  • Concomitant MAO inhibitors: avoid due to potential serotonin‑related toxicity.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Tianeptine Sodium may interact with several drug classes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe serotonin‑related effects.
  • Central nervous system depressants (e.g., benzodiazepines, alcohol): additive sedation.
  • Other serotonergic agents (e.g., SSRIs, SNRIs): potential for serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP450 inhibitors (e.g., fluoxetine, erythromycin): may increase plasma levels.
  • Antihypertensives: possible additive hypotensive effect.
  • Antidiabetic drugs: monitor glucose control.
  • Other antidepressants: assess for overlapping side‑effect profiles.
  • NSAIDs: increased risk of gastrointestinal bleeding.

Frequently Asked Questions

Nobixal contains tianeptine sodium and is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and impaired concentration by acting on serotonergic and glutamatergic pathways.

Tianeptine sodium enhances serotonin reuptake, which paradoxically increases serotonergic signaling, and simultaneously modulates glutamate transmission. These actions promote neuroplastic changes and improve stress‑related neural circuitry, resulting in an antidepressant effect distinct from traditional SSRIs.

The dosage of Nobixal is individualized by a qualified prescriber based on the patient’s clinical condition, response, and tolerability. Specific dosing regimens are not disclosed publicly and should be determined by a healthcare professional.

Safety data for tianeptine sodium in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, and its excretion in breast milk has not been established. Use only if the potential benefit justifies the potential risk.

To request Nobixal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Unlike selective serotonin reuptake inhibitors (SSRIs), Nobixal enhances serotonin reuptake and modulates glutamate transmission, offering a different mechanism that may be beneficial for patients who do not respond to conventional SSRIs or SNRIs. Its side‑effect profile also differs, with fewer sexual dysfunction reports but a distinct set of potential adverse reactions.

Store Nobixal at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Nobixal is taken orally, usually with a glass of water. It can be administered with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any dietary considerations.

Serious risks include the emergence of suicidal thoughts or behaviors, severe liver injury, pancreatitis, anaphylactic reactions, and seizures. Patients should be monitored closely for any of these events, and immediate medical attention is required if they occur.

Nobixal is contraindicated in patients currently taking monoamine oxidase inhibitors, those with known hypersensitivity to tianeptine sodium, and individuals with severe hepatic impairment. Caution is also advised for patients with a history of seizures, renal dysfunction, or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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